Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty’s syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies ...

Evolutionarily conserved, “natural” (n)IgM is broadly reactive to both self and foreign antigens. Its selective deficiency leads to increases in autoimmune diseases and infections. In mice, nIgM is secreted independent of microbial exposure to bone marrow (BM) and spleen B-1 cell–derived plasma cells (B-1PC), generating the majority of nIgM, or by B-1 cells that remain non-terminally differentiated ...

b-1, 4-Galactosyltransferase gene (B4GALT) family consists of seven members, which encode corresponding enzymes known as type II membrane-bound glycoproteins. These enzymes catalyze the biosynthesis of different glycoconjugates and saccharide structures, and have been recognized to be involved in various diseases. In this study, we sought to determine the expressional profiles of B4GALT family ...

This article aims to provide insight into how babymoon tourism can contribute to well-being by using a multimethod approach, combining autoethnography and netnography. The findings show that mothers-to-be experience well-being derived from co-creation and meaning. Participation in activities and everyday-like events at the destination can lead to happiness and improved quality of life. Self-development, ...

Background: <br> Bacillus anthracis, which causes anthrax in humans and animals, is enzootic in parts of the U.S. state of Texas where cases are typically reported in animals annually. The gamma phage lysis assay is a common diagnostic method for identifcation of B. anthracis and is based on the bacterium’s susceptibility to lysis. This test has been shown to be 97% specifc for B. anthracis, as ...

The last few years have seen a paradigm shift in European security. NATO and Russia are once again stepping up their military activities and building their military arsenals, as deep mistrust and the fear of unintended military escalation seem to have returned. Over the last few decades, such concerns could be mitigated by an interlocking web of arms control and confidence- and security-building ...

In order to compile a list of all the backlinks for a given webpage, we need knowledge about all the outgoing links on the web. Traversing the web and storing all the backlink data in a database allows us to efficiently retrieve the list of backlinks for a web page on demand. However, the web consists of billions of backlinks which translates to terabytes of data. As the web is continuously evolving, ...

This study discusses and estimates the backward-bending supply curve, using data for three years over a six-year time span from the inshore purse seine fishery in Khanh Hoa province, Vietnam. Four different models are developed for estimation based on fisheries data, in the absence of stock survey data. The estimated maximum sustainable yield for the anchovy in south-central Vietnam ranges from ...

An investigation was conducted to identify the allochthonous microbiota (entire intestine) and the autochthonous microbiota in proximal intestine (PI) and distal intestine (DI) of four species of Indian air-breathing fish (climbing perch; Anabas testudineus, murrel; Channa punctatus, walking catfish; Clarias batrachus and stinging catfish; Heteropneustes fossilis) by PCR based denaturing gradient ...

Bacteria carry antibiotic resistant genes on movable sections of DNA that allow them to select the relevant genes on demand.