WAIF started out in 2002 and the overall goal is to make the computers automatically search for relevant information based on the user’s preferences, and to push this information directly to the user wherever he/she is and to whatever device he/she has available. In other words, make the machines serve us, with as little human interaction as possible. This thesis focuses on a specific part of this ...

Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...

The selective autophagy receptor p62/sequestosome 1 (SQSTM1) interacts directly with LC3 and is involved in oxidative stress signaling in two ways in mammals. First, p62 is transcriptionally induced upon oxidative stress by the NF-E2-related factor 2 (NRF2) by direct binding to an antioxidant response element in the p62 promoter. Second, p62 accumulation, occurring when autophagy is impaired, leads ...

Some countries have a demography that makes it necessary to maintain relatively small pacemaker centres. We wanted to assess the quality of pacemaker surgery in two such hospitals. Through patient records we gathered information on ∼535 consecutive primary pacemaker implantations in two small pacemaker centres with 30 and 80 annual operations, respectively. All patients were followed for 3 years. ...

<i>Background</i>: Cross-country skiing (XCS) racing, a popular international winter sport, is complex and challenging from physical, technical, and tactical perspectives. Despite the vast amount of research focusing on this sport, no review has yet addressed the pacing strategies of elite XCS racers or the factors that influence their performance. The aim was to review the scientific literature ...

Bakgrunn: Løpsutviklingen som utholdenhetsidretter har stor innflytelse på prestasjonen. Selv om flere studier har undersøkt løpsutvikling i flere idretter, er det lite informasjon om løpsutviklingen til langdistanse langrennsløpere, og for begge kjønn. Denne masteroppgaven undersøker hva slags løpsutviklingen utøverne adapterer i et langdistanseløp, og om ulike terreng vil påvirke deres løpsutvikling. ...

<i>Background</i>: Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, trigger biodegradation of polymer-based nanoparticles (NPs) bearing pinacol-type boronic ester groups. These NPs may selectively release their cargo, in this case paclitaxel (PTX), at the high levels of ROS present in the intracellular environment of inflamed tissues and most tumors.<p> <p><i>Purpose</i>: ...

A cohort of 89 healthy children was recruited from Tromsø during 2009. All children had a radiograph and an MRI of the left wrist, while 74 met for a follow-up study during 2013. The initial examination showed that all children had numerous bony depressions in one or more of the carpal bones, and that these depressions could mimic erosions as defined in the adult rheumatoid arthritis literature, and ...

This article discusses the medieval English mystic Julian of Norwich’s autobiographical text <i>Revelations of Divine Love</i> and the significance of physical pain in Julian’s holy visions. Applying Anne H. Hawkins’ idea of the ‘myth of rebirth’, the article argues that although Julian’s work is not a narrative about illness as such, it may nevertheless be read as a medieval pathography or as a ...

Objectives<br> Although pain is a significant symptom in chronic fatigue syndrome (CFS), pain is poorly understood in adolescents with CFS. The aim of this study was to explore pain distribution and prevalence, pain intensity and its functional interference in everyday life, as well as pressure pain thresholds (PPT) in adolescents with CFS and compare this with a control group of healthy adolescents ...