The zebrafish is an exciting model organism with a lot to offer and many possible areas of application. Toxicity assays using zebrafish embryos are becoming increasingly popular with the pharmaceutical industry as a tool to bridge the gap between conventional cell based screens and animal testing. The main aim of this project was to explore the zebrafish as a model system for use in safety pharmacology, ...

In the context of computer networks, decentralization is a network architecture that distributes both workload and control of a system among a set of coequal participants. Applications based on such networks enhance trust involved in communication by eliminating the external author- ities with self-interests, including governments and tech companies. The decentralized model delegates the ownership ...

The Chukotian writer Yuri Rytkheu, born in 1930, is the author of a large number of books, all of them dealing with the hard life of the small indi- genous people to which he belongs. The last century has seen two im- portant turning-points in this people's history: the establishment of Soviet power and its fall. Neither event has lead to an improvement of the situ- ation. The never-ending hardships ...

Bacterial multi-drug resistance is a major health problem worldwide. Inhibition of bacterial virulence is suggested to be a promising strategy in the development of new antibacterial drugs. The present work has focused on identifying new inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN, LasB) and aureolysin (ALN), which are all zinc metalloproteases (MPs) using enzyme ...

Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as putative inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) and the human zinc metalloproteases, ...

The increasing penetration of renewable energy resources (RES) in transmission system operating conditions require a suitable test system and a dataset to cope with current issues. RES penetration remarkably affects day-ahead market outcomes regarding zonal prices and dispatched generation levels. For this purpose, zonal day-ahead energy market models in the presence of RES in the generation mix ...

Free traveling Rossby wave normal modes (RNMs) are often investigated through large-scale space-time spectral analyses, which therefore is subject to observational availability, especially in the mesosphere. Ground-based mesospheric observations were broadly used to identify RNMs mostly according to the periods of RNMs without resolving their horizontal scales. The current study diagnoses zonal ...

Autophagy is an evolutionary conserved process by which eukaryotic cells undergo self-digestion of cytoplasmic components. Here we report that a novel Drosophila immunophilin, which we have named Zonda, is critically required for starvation-induced autophagy. We show that Zonda operates at early stages of the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition. ...

Svalbard fjords are facing a significant increase in Atlantic water inflow, which influences all ecosystem components, thus the objective of this study was to assess how recent Atlantification impacts the functioning of zooplankton community. For this purpose, two year-round operating sediment traps and associated hydrographic instruments, providing continuous time series of zooplankton and sediment ...