Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ...

Perturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established, recent findings illustrate that the atypical MAP kinase ERK3/4-MK5 may also be involved in tumorigenic processes. Remarkably, the ERK3/4-MK5 ...

BACKGROUND: MicroRNAs (miRNAs) regulate expression of many cancer-related genes through posttranscriptional repression of their mRNAs. In this study we investigate the proto-oncogene MYCN as a target for miRNA regulation.<p> <p>METHODS: A luciferase reporter assay was used to investigate software-predicted miRNA target sites in the 30 -untranslated region (30 UTR) of MYCN. The miRNAs were ...

<p><i>Motivation</i>: The Tundra Trait Team (TTT) database includes field‐based measurements of key traits related to plant form and function at multiple sites across the tundra biome. This dataset can be used to address theoretical questions about plant strategy and trade‐offs, trait–environment relationships and environmental filtering, and trait variation across spatial scales, to validate satellite ...

Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We ...

This article addresses the methodological aspects of a multi-voiced, collaborative ethnographic research process, in particular how video can enhance and amplify this research endeavour. The authors illustrate and discuss how experimental filmic methodologies can help to capture processes of becoming in a collaborative research endeavour, both enabling the development and production of diverse ...

<p>The Eocene of Spitsbergen, Svalbard, has received considerable attention in the literature because of its spectacular seismic-scale clinforms exposed along many fiords and valleys. High quality outcrops enables downdip tracing of facies belts from the proximal shelf through the shelf-edge and down-slope into the basin floor. Previous publications particularly focused on the shelf-edge to slope ...

We report observations of heat and momentum fluxes measured in the ice-ocean boundary layer from four drift stations between January and June 2015, covering from the typical Arctic basin conditions in the Nansen Basin to energetic spots of interaction with the warm Atlantic Water branches near the Yermak Plateau and over the North Spitsbergen slope. A wide range of oceanic turbulent heat flux values ...

I denne oppgaven har jeg jobbet ut fra følgende problemstilling: å identifisere hvilke elementer ved en guidet tur i Oslo, inkludert egenskaper ved en Oslo-guide, en turist vektlegger og hvordan Oslo-guider kan bruke denne informasjonen til å øke sin egen kompetanse. Mitt teoretiske rammeverk for denne oppgaven er teori tilknyttet guiderollen og guidens funksjon. Samt teori som omtaler hvordan ...