From the beginning of my academic career, teaching has always been one of the important parts of my academic duties, and my teaching philosophies develop over time. I agree with Worley (2001) that there is a difference between effective and great teachers. He argues that while effective teachers are skilled, great teachers have a mission, a teaching impulse, and a vocation to teach. Being a great ...

Traditional strict separation of fungi into ecological niches as mutualist, parasite or saprotroph is increasingly called into question. Sequences of assumed saprotrophs have been amplified from plant root interiors, and several saprotrophic genera can invade and interact with host plants in laboratory growth experiments. However, it is uncertain if root invasion by saprotrophic fungi is a widespread ...

The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of a bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the Dickkopf family of Wnt regulators. It functions as a tumor suppressor in a range of cancers, including neuroblastoma. MYCN was recently found to downregulate DKK3 mRNA. In this study, we show that MYCN knockdown in ...

Background: MyD88 directly interacts and affects IRF activation in mammals, but no information has been available about lower vertebrates.<p> <p>Results: Transgenic MyD88 interacts with IRF3 and IRF7A/B and modulates the IRF-induced IFN response and accumulates in aggresomes in Atlantic salmon. <p>Conclusion: MyD88 is involved in the regulation of the IRF-induced IFN response in Atlantic ...

Background: Myelinated retinal nerve fibres (MRNFs) are congenital anomalies of the fundus that occur in about 1% of the population. Clinically, they appear as grey or white well-separated patches with feathery borders along the retinal nerve fibre layer. MRNF has been reported to occur in association with some ocular parameters as well as stroke. However, most cases of MRNF occur in isolation and ...

Innen ernæringsepidemiologien er vi i stor grad avhengige av å estimere inntak av mat og næringsstoffer basert på selvrapportering, til tross for at denne tilnærmingen er beheftet med målefeil. Graden av målefeil har betydning for analyser og tolkning av resultater, så metodene vi bruker bør være så valide som mulig. Å utvikle brukervennlige kostholdsmetoder som reduserer belastning for deltaker kan ...

Mykobakterier er utbredt i naturen, med et stort antall beskrevne arter, hvorav noen er assosiert med sykdom hos mennesker og dyr. Mykobakteriose hos fisk er vanligvis en kronisk sykdom, med varierende dødelighet, og kan forårsake store økonomiske tap.

The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...

Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ...

The overall aim of this thesis was to increase our knowledge related to the underlying mechanisms of diabetes-induced cardiomyopathy. The primary objective of the first two papers was to elucidate the role of the reactive oxygen species (ROS) producing enzyme, NADPH oxidase 2 (NOX2), in the development of cardiac dysfunction in obesity/diabetes. We also wanted to examine the potential link between ...