Knappskog, Stian; Berge, Elisabet Ognedal; Chrisanthar, Ranjan; Geisler, Stephanie; Staalesen, Vidar; Leirvaag, Beryl; Yndestad, Synnøve; de Faveri, Elise Norheim; Karlsen, Bård Ove; Wedge, David C.; Akslen, Lars A.; Lilleng, Peer Kåre; Løkkevik, Erik; Lundgren, Steinar; Østenstad, Bjørn; Risberg, Terje; Mjaaland, Ingvil; Aas, Turid; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-08)
Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single
gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways
affecting cellular mechanisms such as apoptosis, senescence, or DNA repair. In
support of this hypothesis, we have previously shown inactivation of either TP53 or its
key activators CHK2 and ATM to predict resistance ...