Blar i forfatter "Segadimo, Kealebile"
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To study ammonia metabolism through activities of glutamine synthetase (GS) and phosphate-activated glutaminase in pigs with acute liver failure
Segadimo, Kealebile (Master thesis; Mastergradsoppgave, 2008-08-16)Background: Acute liver failure results in disturbed ammonia metabolism, urea synthesis capacity decreases and hyperammonemia develops. Glutamine synthetase (GS) detoxifies (temporarily) ammonia to glutamine. However, glutamine is split by phosphate-activated glutaminase (PAG) again to ammonia and glutamate. We aimed to investigate whether organ specific changes in both GS and PAG activities are ...