Browsing by Author "Johnson, Kenneth"
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Anomalous dispersion analysis of inhibitor flexibility : a case study of the kinase inhibitor H-89
Pflug, Alexander; Johnson, Kenneth; Engh, Richard Alan (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)With its ability to show the interactions between drug-target proteins and small-molecule ligands, X-ray crystallography is an essential tool in drug-discovery programmes. However, its usefulness can be limited by crystallization artifacts or by the data resolution, and in particular when assumptions of unimodal binding (and isotropic motion) do not apply. Discrepancies between the modelled crystal ... -
CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8
Johnson, Kenneth; Ve, Thomas; Larsen, Øivind; Pedersen, Rolf B.; Lillehaug, Johan R.; Jensen, Harald B; Helland, Ronny; Karlsen, Odd Andre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)
Assefa, Netsanet Gizaw; Niiranen, Laila; Johnson, Kenneth; Leiros, Hanna-Kirsti S.; Smalås, Arne O.; Willassen, Nils Peder; Moe, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-25)Uracil-DNA N-glycosylase from Atlantic cod (cUNG) shows cold-adapted features such as high catalytic efficiency, a low temperature optimum for activity and reduced thermal stability compared with its mesophilic homologue human UNG (hUNG). In order to understand the role of the enzyme–substrate interaction related to the cold-adapted properties, the structure of cUNG in complex with a bacteriophage ... -
Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
Pedersen, Hege Lynum; Johnson, Kenneth; McVey, Colin; Leiros, Ingar; Moe, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-01)