Blar i forfatter "Ernst, Thomas"
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A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib
Ernst, Thomas; Gruber, Franz; Mikkola, Ingvild; Pelz-Ackermann, Oliver; Maier, J; Pfirrmann, M; Muller, MC; Porkka, Kimmo; Niederwieser, D; Hochhaus, A; Lange, T (Journal article; Tidsskriftartikkel; Peer reviewed, 2009) -
The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to second-line nilotinib or dasatinib treatment in patients with chronic myeloid leukemia
Lange, Thoralf; Ernst, Thomas; Gruber, Franz; Maier, Jacqueline; Cross, Michael; Müller, Martin C.; Niederwieser, Dietger; Hochhaus, Andreas; Pfirrmann, Markus (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-05)The BCR-ABL T315I mutation causes resistance to imatinib, nilotinib and dasatinib in chronic myeloid leukemia. Forty BCR-ABL positive patients with imatinib resistance were analyzed for T315I mutated clones after six months on nilotinib or dasatinib treatment by quantitative allele-specific ligation polymerase chain reaction with a sensitivity of 0.05%. Ligation polymerase chain reaction revealed ...