Blar i forfatter "Cheng, Lei"
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Comprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs
Cheng, Lei; Gao, Shuhang; Song, Xiaobo; Dong, Weijie; Zhou, Huimin; Zhao, Lifen; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Glycosylation has significant effects on cancer progression. Fucosylation is one of the most important glycosylation events involved in hepatocellular carcinoma (HCC). Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating ... -
MiR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4
Zhao, Lifen; Feng, Xiaobin; Song, Xiaobo; Zhou, Humin; Zhao, Yongfu; Cheng, Lei; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-16)Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV ... -
Reversal effect of ST6GAL 1 on multidrug resistance in human leukemia by regulating the PI3K/Akt pathway and the expression of P-gp and MRP1
Ma, Hongye; Cheng, Lei; Hao, Keji; Li, Yanping; Song, Xiaobo; Zhou, Huimin; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)