Wickström, Malin; Dyberg, Cecilia; Milosevic, Jelena; Einvik, Christer; Calero, Raul; Sveinbjørnsson, Baldur; Sandén, Emma; Darabi, Anna; Siesjö, Peter; Kool, Marcel; Kogner, Per; Baryawno, Ninib; Johnsen, John Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-25)
The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly
overexpressed in cancers and is implicated in the development of chemoresistance. The use
of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency.
As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT
expression in multiple cancers. Here we show a ...