Renal cancer cells constitute a paradigm of tumor cells with a glycolytic reprogramming which drives metabolic alterations favouring cell survival and transformation. We studied the expression and activity of pyruvate dehydrogenase kinases (PDK1-4), key enzymes of the energy metabolism, in renal cancer cells. We analysed the expression, subcellular distribution and clinicopathological correlations ...

The thesis sets out to explore the ways that mood is adapted from Highsmith’s novels The Talented Mr. Ripley (1955) and The Price of Salt (1952) to Anthony Minghella’s The Talented Mr. Ripley (1999) and Todd Haynes’s Carol (2015), respectively. The aim is to show the diverging ways in which the novels and the films express the quintessential Highsmith story through mood, and to show how these diverging ...

Background Trauma-induced coagulopathy in traumatic brain injury (TBI) remains associated with high rates of complications, unfavorable outcomes, and mortality. The underlying mechanisms are largely unknown. Embedded in the prospective multinational Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, coagulation profiles beyond standard conventional ...

What today's browsers offer in customization, personalization and functionality can be improved. In this thesis a application, in the form of a chrome extension that extends a web browser's functionality, and that offers customization and personalization has been designed and implemented. The functions implemented in the extension simplifies the access and availability of information to the user ...

The dependent variable in the Rotterdam model is shown to consist of two additive components: the proportionate change in the average product weight consumed by existing buyers and the proportionate change in the share of total consumers who actually purchase the product. Applying the extended model to household data on salmon consumption in France, results suggest prices have a larger effect on ...

Janda 2012 and Janda et al. 2013 presented the hypothesis that Russian aspectual prefixes serve as verb classifiers, similar to verb classifiers identified in Australian languages, and as the verbal analogs of numeral classifiers found primarily in Asia and Central America. We further extend this hypothesis in two directions. First, we make the point that the distinction between sortal classifiers ...

The main goal of this thesis is to build up detailed constructions and give complete proofs for the extension functors of modules and groups, which we define using cohomology functors. Further, we look at the relations that appear between these and short exact sequences of modules, respectively groups. We calculate also several concrete cohomology groups, and build extensions that are described by ...

We find that summer methane (CH4) release from seabed sediments west of Svalbard substantially increases CH4 concentrations in the ocean but has limited influence on the atmospheric CH4 levels. Our conclusion stems from complementary measurements at the seafloor, in the ocean, and in the atmosphere from land-based, ship and aircraft platforms during a summer campaign in 2014. We detected high ...

<b>Background</b> <br> Qualitative research findings are increasingly used to inform decision-making. Research has indicated that not all quantitative research on the effects of interventions is disseminated or published. The extent to which qualitative researchers also systematically underreport or fail to publish certain types of research findings, and the impact this may have, has received ...