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Now showing items 29320-29339 of 32816

    • Synthesis of XTH inhibitors 

      Pettersen, Martin (Master thesis; Mastergradsoppgave, 2019-05-15)
      XTH er en gruppe enzymer som ble oppdaget tidlig på 90 tallet og muligens er involvert i Cuscuta infeksjonen av tomater. En nylig studie gjort ved arktisk og marin biologi UIT viser at Brilliant Blue R250 fungerer som en god inhibitor mot disse enzymene. I dette prosjektet ble det fokusert på å syntetisere strukturelt like molekyler for å potensielt øke vannløseligheten og inhibitoraktiviteten. ...

    • Synthesis of β-substituted β-aminoboronates 

      Thomassen, Ivar Kristian (Master thesis; Mastergradsoppgave, 2013-05)
      Recent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific ...

    • Synthesis, bioactivity testing, and structure elucidation of antimicrobial peptide analogues derived from Synoicum Turgens 

      Kristensen, Johannes (Mastergradsoppgave; Master thesis, 2023-05-15)
      A method was developed for synthesizing and isolating two DRPs, with varying levels of success affected by difficulties in the purification process and human error. However, it has shed light on some of the difficulties that may occur and suggestions on how they could be improved. The method developed structure elucidation through sequential reduction and alkylation of the disulfide bridges proved ...

    • Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis 

      Solum, Eirik Johansson; Cheng, Jing-Jy; Sylte, Ingebrigt; Vik, Anders; Hansen, Trond Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-27)
      The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 10 analogs of 2-methoxyestradiol are reported. These efforts revealed that the analog with a 4-pyridine ring in the 17-position, in combination with 2-ethyl- and 3-sulfamate substituents on the steroid A-ring, is the most interesting anti-cancer agent. This compound showed potent inhibitory effects against ...

    • Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618 

      Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege; Hansen, Trond Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)
      Abstract: Herein, we describe the synthesis, biological evaluation and molecular docking of the selective PPARb/ d antagonist (4-methyl-2-(4-(trifluoromethyl)phenyl)-N-(2-(5-(trifluoromethyl)-pyridin-2-ylsulfonyl) ethyl)thiazole-5-carboxamide)), CC618. Results from in vitro luciferase reporter gene assays against the three known human PPAR subtypes revealed that CC618 selectively antagonizes ...

    • Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors 

      Sjøli, Stian; Nuti, Elisa; Camodeca, Caterina; Bilto, Irina; Rossello, Armando; Winberg, Jan-Olof; Sylte, Ingebrigt; Adekoya, Olayiwola (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-28)
      Enzymes of the M4 family of zinc-metalloproteinases are virulence factors secreted from gram-positive or gram-negative bacteria, and putative drug targets in the treatment of bacterial infections. In order to have a therapeutic value such inhibitors should not interfere with endogenous zinc-metalloproteinases. In the present study we have synthesised a series of hydroxamate derivatives and validated ...

    • Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors 

      Åstrand, Ove Alexander Høgmoen; Viktorsson, Elvar Örn; Kristensen, Aleksander Lim; Ekeberg, Dag; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon; Gabrielsen, Mari; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål; Kase, Eili Tranheim (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-26)
      Liver X Receptor (LXR) modulators have shown potential as drugs since they target genes affecting metabolism and fatty acid synthesis. LXR antagonists are of particular interest since they are able to reduce the synthesis of complex fatty acids and glucose uptake. Based on molecular modeling, five new cholesterol mimics were synthesized, where four contained a hydroxyl group in the 22-S-position. ...

    • Synthesis, Spectroscopy, Electrochemistry and DFT of Electron-Rich Ferrocenylsubphthalocyanines 

      Conradie, Jeanet; Swarts, Petrus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)
      A series of novel ferrocenylsubphthalocyanine dyads Y-BSubPc(H)<sub>12</sub> with ferrocenylcarboxylic acids Y-H = (FcCH<sub>2</sub>CO<sub>2</sub>-H), (Fc(CH<sub>2</sub>)<sub>3</sub>CO<sub>2</sub>-H) or (FcCO(CH<sub>2</sub>)<sub>2</sub>CO<sub>2</sub>-H) in the axial position were synthesized from the parent Cl-BSubPc(H)<sub>12</sub> via an activated triflate-SubPc intermediate. UV/Vis data revealed ...

    • Synthesizing a Talking Child Avatar to Train Interviewers Working with Maltreated Children 

      Salehi, Pegah; Hassan, Syed Zohaib; Lammerse, Myrthe; Shafiee Sabet, Saeed; Riiser, Ingvild; Røed, Ragnhild Klingenberg; Sinkerud Johnson, Miriam; Hicks, Steven; Thambawita, Vajira; Powell, Martine; Lamb, Michael E.; Baugerud, Gunn Astrid; Halvorsen, Pål; Riegler, Michael (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-01)
      When responding to allegations of child sexual, physical, and psychological abuse, Child Protection Service (CPS) workers and police personnel need to elicit detailed and accurate accounts of the abuse to assist in decision-making and prosecution. Current research emphasizes the importance of the interviewer’s ability to follow empirically based guidelines. In doing so, it is essential to implement ...

    • Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmission 

      Moodie, Lindon; Zuzek, Monika; Frangez, Robert; Andersen, Jeanette hammer; Hansen, Espen; Olsen, Elisabeth Klungerbo; Cergolj, Marija; Sepcic, Kristina; Hanssen, Kine Østnes; Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-09)
      The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library of twelve synthetic phenethylamine analogs, 2a–7a and 2b–7b, containing tertiary and ...

    • The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model 

      Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-27)
      The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host defence are important strategies in the search for novel antimicrobial drugs. We investigated the inflammatory response of the synthetic short antimicrobial peptide LTX21 in two ...

    • Synthetic Aperture Focusing of Ultrasonic Data From Multilayered Media Using an Omega-K Algorithm 

      Skjelvareid, Martin H.; Olofsson, Tomas; Birkelund, Yngve; Larsen, yngvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The synthetic aperture focusing technique (SAFT) is used to create focused images from ultrasound scans. SAFT has traditionally been applied only for imaging in a single medium, but the recently introduced phase shift migration (PSM) algorithm has expanded the use of SAFT to multilayer structures. In this article we present a similar focusing algorithm called multi-layer omega-k (MULOK), which ...

    • Synthetic aperture radar compact polarimetry for sea ice surveillance 

      Espeseth, Martine Mostervik (Master thesis; Mastergradsoppgave, 2015-06-26)
      The focus of this thesis is to investigate the use of synthetic aperture radar (SAR) compact polarimetry for studies of sea ice. Data obtained from quad-polarimetric SAR systems have already been studied extensively for sea ice monitoring. This thesis focuses on finding parallels to quad-polarimetric features from the compact-polarimetric data. This is achieved through the reconstruction of a pseudo ...

    • Synthetic Aperture Radar Remote Sensing of Operational Platform Produced Water Releases 

      Skrunes, Stine; Johansson, Malin; Brekke, Camilla (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      Oil spill detection services based on satellite synthetic aperture radar (SAR) frequently detect oil slicks close to platforms due to legal releases of produced water. Separating these slicks from larger releases, e.g., due to accidental leakage is challenging. The aim of this work is to investigate the SAR characteristics of produced water, including the typical appearance in HH/VV data, possible ...

    • Synthetic aperture ultrasound imaging with application to interior pipe inspection 

      Skjelvareid, Martin Hansen (Doctoral thesis; Doktorgradsavhandling, 2012-09-07)
      This thesis is concerned with synthetic aperture focusing of ultrasonic pulse-echo measurements, with application to multilayered media and cylindrical structures. The work is motivated by the need for accurate methods for non-destructive testing of pipelines, particularly water distribution pipelines. By improving the lateral resolution in ultrasonic measurements, the synthetic aperture algorithms ...

    • Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin 

      Sivertsen, Annfrid; Isaksson, Johan; Leiros, Hanna-Kirsti S.; Svenson, Johan; Svendsen, John Sigurd; Brandsdal, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release 

      de Boer, Eline; Sokolova, Marina; Quach, Huy Quang; Mc Adam, Karin Ekholt; Götz, Maximilian P.; Chaban, Viktoriia; Vaage, Ingvar Jarle; Fageräng, Beatrice Linnea Christina; Woodruff, Trent M.; Garred, Peter; Nilsson, Per; Mollnes, Tom Eirik; Pischke, Soeren (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-01)
      Bacterial and mitochondrial DNA, sharing an evolutionary origin, act as danger-associated molecular patterns in infectious and sterile inflammation. They both contain immunomodulatory CpG motifs. Interactions between CpG motifs and the complement system are sparsely described, and mechanisms of complement activation by CpG remain unclear. Lepirudin-anticoagulated human whole blood and plasma were ...

    • The synthetic perfect from Indo-Iranian to Late Vedic 

      Dahl, Eystein (Chapter; Bokkapittel, 2020)
      This paper outlines the origin and development of the synthetic Perfect from Indo-Iranian, the reconstructed common ancestral stage of the Iranian and Indo-Aryan languages, to Vedic, the oldest attested stage of Old Indo-Aryan. Comparative evidence from Old Iranian, Homeric Greek and a number of other Indo-European languages shows that this morphological category ultimately stems from Proto-Indo-European. ...

    • A Synthetic Route to Quaternary Pyridinium Salt-Functionalized Silsesquioxanes 

      Kostenko, Nataliya; Gottfriedsen, Jochen; Hilfert, Liane; Edelmann, Frank T (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      A synthetic route to potentially biocidal silsesquioxanes functionalized by quaternary pyridinium functionalities has been developed. N-Alkylation reactions of the precursor compounds 4-(2-(trimethoxysilyl)ethyl)-pyridine (5) and 4-(2-trichloro-silylethyl)pyridine (6) with iodomethane, n-hexylbromide, and n-hexadecylbromide cleanly afforded the corresponding N-alkylpyridinium salts (7–10). The ...

    • Synthetic wavelength scanning interferometry for 3D surface profilometry with extended range of height measurement using multi-colour LED light sources 

      Mann, Priyanka; Dubey, Vishesh Kumar; Ahmad, Azeem; Butola, Ankit; Mehta, Dalip Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-05)
      We report three-dimensional surface profilometry with extended range of height measurements using synthetic wavelength scanning interferometry without tunable filters, wavelength-tuning lasers, grating elements. We have used inexpensive multiple colour light emitting diodes (LEDs) and operate them sequentially one by one or combination of two or more colours simultaneously to visualize synthetic ...