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Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-15)DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, ... -
Hyposensibilisering med katteallergenekstrakter : en litteraturstudie.
(Master thesis; Mastergradsoppgave, 2008-09-15)Denne litteraturstudien omhandler spesifikk immunterapi (SIT) med katteallergenekstrakter. Ved SIT (også benevnt ”hyposensibilisering” eller ”allergivaksine”) tilføres pasienten ett eller flere allergen over tid med formål å minske pasientens følsomhet ovenfor aktuelle allergen. SIT administreres subcutant (SCIT) eller sublingualt (SLIT) Felint protein D 1 (Fel d 1)er vanligste årsak til ... -
Hypotermi og hjertesvikt
(Conference object; Konferansebidrag, 2020) -
Hypotermi og væskebehandling
(Master thesis; Mastergradsoppgave, 2002) -
Hypotese verifisering av tilslagstype innflytelse på CMOD av fiber betong.
(Master thesis; Mastergradsoppgave, 2023-05-15)Tilsetting av fiber i betong har vært noe som lenge har vært benyttet for å tilføre strekkegneskaper i betongen og hindre blant annet riss i betongen. Det har i de siste årene vært et ønske om å undersøke om det er forsvarlig å bruke fiber betong i bærende konstruksjoner, og ikke kun i fundamenter og sprøytebetong som fiber har normalt sett vært benyttet til. Etter publiseringen av NB.38 i 2020 har ... -
Hypothalamic - pituitary stress axis in female patients with bulimia nervosa. Neuroendocrine diurinal regulation of hunger and satiety in women with bulimia nervosa.
(Master thesis; Mastergradsoppgave, 2002-11) -
Hypothalamic clock involvement in cluster headache. A study of chronobiology, sleep, and cranial autonomic function in cluster headache
(Doctoral thesis; Doktorgradsavhandling, 2016-10-24)Cluster headache has been claimed to be a chronobiological disorder because of its striking periodic occurrence. This suggests that the biological clock is involved in the pathophysiology of the disease, but few researchers have studied this in depth. In this thesis, we have studied several aspects of chronobiology in cluster headache patients. First, we assessed the periodicity of headache attacks, ... -
Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognized as a principal cause for a high mortality rate in these patients. We assessed both ... -
Hypothermia-induced myocardial calcium overload –a study of intracellular Ca2+ handling during profound hypothermia and rewarming
(Doctoral thesis; Doktorgradsavhandling, 2016-09-30)We performed randomized controlled experimental studies in an intact animal model and in isolated cardiac myocytes with the following aims: To establish an in vivo model for measuring cardiac intracellular [Ca2+] ([Ca2+]i) in an anesthetized rat with maintained spontaneous circulation. In this model we could sort out if alterations in Ca2+ homeostasis take place in response to hypothermia and ... -
Hypothermic cardiac arrest far away from the center providing rewarming with extracorporeal circulation.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)A 41-year-old man suffered hypothermic cardiac arrest after water immersion and was transported to our university hospital by ambulance helicopter for rewarming on cardiopulmonary bypass. He resumed spontaneous cardiac activity 6 h 52 min after cardiac arrest and recovered completely. -
Hypothetical interventions and risk of atrial fibrillation by sex and education: application of the parametric g-formula in the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)Aims - To use the parametric g-formula to estimate the long-term risk of atrial fibrillation (AF) by sex and education under hypothetical interventions on six modifiable risk factors.<p> <p>Methods and results - We estimated the risk reduction under hypothetical risk reduction strategies for smoking, physical activity, alcohol intake, body mass index, systolic, and diastolic blood pressure in 14 ... -
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-24)<i>Objectives</i> - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. <p> <p><i>Design and setting</i> - A populations-based cohort study with repeated measurements, the Tromsø Study. <p> <p><i>Primary outcome measure</i> - Myocardial infarction. <p> <p>< ... -
The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-16)Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant ... -
Hypoxia and hypotension in patients intubated by physician staffed helicopter emergency medical services - a prospective observational multi-centre study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators of care provided by emergency medical services. Excluding cardiac arrests, critical trauma and non-trauma patients remain the two major groups to which helicopter emergency ... -
Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-04)Abnormal circulation in solid tumors results in hypoxia, which modulates both tumor intrinsic malignant properties as well as anti-tumor immune responses. Given the importance of hypoxia in glioblastoma (GBM) biology and particularly in shaping anti-tumor immunity, we analyzed which immunomodulatory genes are differentially regulated in response to hypoxia in GBM cells. Gene expression analyses ... -
Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-19)The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic ... -
Hypoxic markers and prognosis in non-small cell lung cancer (NSCLC)
(Doctoral thesis; Doktorgradsavhandling, 2011-11-30)Lungekreft er uten sammenligning den kreftsykdommen som tar flest liv i Norge og 6 personer dør i gjennomsnitt hver dag av sykdommen. De som blir oppdaget i et tidlig stadium kan opereres med mål om å bli kurert. Likevel dør nesten halvparten av de som blir operert av lungekreft og behovet for nye behandlingsalternativer er stort. Andersens funn viser at markører for lave surstoff nivåer og ... -
Hyppighet og alvorlighetsgrad av selvopplevde menstruasjonssymptomer og bivirkninger ved bruk av hormonell prevensjon, sett i sammenheng med fysisk aktivitet i idrett og trening blant norske håndballspillere
(Master thesis; Mastergradsoppgave, 2023-05-15)Bakgrunn: Kvinner er svært underrepresentert når det gjelder idrett og trening i vitenskapelig forskning sammenlignet med menn. En forståelse av symptomer i menstruasjonssyklusen og bivirkninger ved bruk av hormonell prevensjon (HP) kan bidra til å optimalisere prestasjon i idrett og trening blant kvinner. Hensikt: Målet med denne oppgaven var å undersøke (1) hvordan naturlig menstruerende (NM), ... -
Hyrekrav - sikring, realisasjon og prioritet
(Master thesis; Mastergradsoppgave, 2015-05-03)Det skal undersøkes hvor «enkelt» det er for ansatte om bord å få utbetalt fordringen i sin helhet, og om det er «farer» som utgjør en trussel mot sjøpanthavere på sikrings- og realisasjonsstadiet. Særlig skal det belyses hvorvidt det er oppstått en «lovfelle» for sjøpanthavere på sikringsstadiet. Det vil si at det skal undersøkes ut ifra rettskildene på område, om det er en lang og tung vei med ... -
Hysterektomi ved kraftige menstruasjonsblødninger: forenklet metodevurdering
(Research report; Forskningsrapport, 2021-06-10)Vi har på oppdrag fra Bestillerforum for nye metoder utarbeidet en forenklet metodevurdering om hysterektomi (kirurgisk fjerning av livmor) ved kraftige menstruasjonsblødninger. Dette er en pilot i et prosjekt innen revurdering som ledes av Helse Midt-Norge RHF. Vi har hentet ut resultater for effekt og sikkerhet og vurderinger av tillit til resultatene for effekt fra en rapport av The National ...
