Viser treff 29392-29411 av 32932

    • Syntactic representations in the bilingual mind: the role of executive function and pragmatics in cross-language priming 

      Wolleb, Anna (Doctoral thesis; Doktorgradsavhandling, 2015-12-10)
      In this thesis I investigate how syntactic forms are represented and accessed in the mind of bilingual children. In particular, I explore the role of executive control and pragmatics in the selection and use of these representations. To do so, I tested a group of Norwegian-English bilingual children and a group of Norwegian age-matched monolinguals in a priming paradigm and in a cognitive task (the ...
    • The syntax and semantics of degree expressions in Spanish 

      Fábregas, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-07)
      This article provides an overview of the syntax and semantics of degree in Spanish, eventually suggesting that degree structure should be viewed as equivalent to aspect in the verbal domain. §1 introduces several of the themes that will be discussed in the article, while §2 introduces the semantics of degree. §3 discusses the basic syntactic properties of degree, particularly with adjectives. §4 ...
    • The syntax and semantics of nominal modifiers in Spanish: interpretations, types and ordering facts 

      Fábregas, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2017)
      This article provides an overview of the main facts and theories regarding nominal modifiers, with attention to the internal division of the low DP-structure (gender, number and N). The article presents first the notion of modification seen from the perspectives of semantics and syntax (§1); adjective classes are discussed in §2. §3 discusses the contrasts between prenominal and postnominal adjectives; ...
    • Syntax Matters: Exploring the Effect of Linguistic Similarity in Third Language Acquisition 

      Jensen, Isabel Nadine; Westergaard, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-06)
      Over the last two decades, the question of to which linguistic cues learners pay attention when they decode a new language has been subject to controversy in the field of third language (L3) acquisition. In this article, we present an artificial language learning experiment that investigated how lexical and syntactic similarities between an artificial L3 and preexisting grammars impact crosslinguistic ...
    • Syntax of Heritage Languages 

      Lohndal, Terje (Chapter; Bokkapittel, 2021)
      In research on heritage speakers, it is often observed that areas of core syntax tend to be resilient and resemble the relevant baseline. This paper discusses this generalization and provides examples of areas that tend to be resilient and areas that are vulnerable. Research into the syntax of heritage speakers has tended to focus on certain areas, such as argument structure and the representation ...
    • The syntax of phonology : A radically substance-free approach 

      Blaho, Sylvia (Doctoral thesis; Doktorgradsavhandling, 2008-06-06)
      ..
    • Syntese av klorerte fettsyrer til bruk som standarder i miljøanalyser 

      Lauknes, Kristian (Master thesis; Mastergradsoppgave, 2007-06-20)
      Mettede C-16 og C-18 klorerte fettsyrer ble syntetisert til bruk som miljøstandarder. De mettede klorerte fettsyrene hører sammen med en ny type miljøgift nemlig klorerte fettsyrer (ClFA). Dette er en type miljøgift som man per dags dato ikke har så mye kunnskap om, men som er blitt påvist i en rekke forskjellige fiskearter. Hvilken effekt de vil ha på mennesker eller andre pattedyr på toppen av ...
    • Synthesis and Antimicrobial Activity of Short Analogues of the Marine Antimicrobial Peptide Turgencin A: Effects of SAR Optimizations, Cys-Cys Cyclization and Lipopeptide Modifications 

      Dey, Hymonti; Simonovic, Danijela; Hagen, Ingrid Sofie Norberg-Schulz; Vasskog, Terje; Fredheim, Elizabeth G. Aarag; Blencke, Hans-Matti; Anderssen, Trude; Strøm, Morten B.; Haug, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-10)
      We have synthesised short analogues of the marine antimicrobial peptide Turgencin A from the colonial Arctic ascidian Synoicum turgens. In this study, we focused on a central, cationic 12-residue Cys-Cys loop region within the sequence. Modified (tryptophan- and arginine-enriched) linear peptides were compared with Cys-Cys cyclic derivatives, and both linear and Cys-cyclic peptides were N-terminally ...
    • Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor 

      Lai, Thu Hang; Toussaint, Magali; Teodoro, Rodrigo; Dukić-Stefanović, Sladjana; Kranz, Mathias; Deuther-Conrad, Winnie; Moldovan, Rareş-Petru; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A<sub>2A</sub>R-tailored therapy. Aiming at the development of a PET radiotracer, we herein ...
    • Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors 

      Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål; Åstrand, Ove Alexander Høgmoen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-02)
      Antibiotics are key drugs in modern healthcare, especially in hospitals, where multiresistant bacteria resides and is a potential threat to human health. In the present work, a new series of adjuvants working synergistically with the carbapenem meropenem, in which a selective zinc-chelating agent was covalently linked to the small bacterial peptide D-Ala-D-Ala, was synthesized and tested against ...
    • Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects 

      Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius; Holen, Torgeir; Hansen, Trond Vidar; Nebb, Hilde Irene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-18)
      Obesity and associated disorders such as metabolic syndrome and type 2 diabetes (T2D) have reached epidemic proportions. Several natural products have been reported as Peroxisome Proliferator-Activated Receptor (PPAR) agonists, functioning as lead compounds towards developing new anti-diabetic drugs due to adverse side effects of existing PPAR drugs. We recently isolated and identified (7E)-9-oxoh ...
    • Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities 

      Håheim, Katja Stangeland; Lindback, Emil; Tan, Kah Ni; Albrigtsen, Marte; Helgeland, Ida Therese Urdal; Clemence, Lauga; Matringe, Theodora; Kennedy, Emily K.; Andersen, Jeanette Hammer; Avery, Vicky M.; Sydnes, Magne Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-30)
      A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine ...
    • Synthesis and inhibitor design of carbapenemase inhibitors 

      Akhter, Sundus (Doctoral thesis; Doktorgradsavhandling, 2018-05-24)
      The efficiency of bacteria in acquiring resistance for their survival ensures a never-ending war against resistance. The only tactic to curtail the resistance crisis is to keep pace with it, e.g. by continuous development of new antibiotics with activity against resistant bacteria or revival of existing agents by inhibiting the mechanisms of resistance. β-lactams are the largest and most widely used ...
    • Synthesis and Molecular Structure of a Copper Octaiodocorrole 

      Thomassen, Ivar Kristian; McCormick, Laura J.; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-09)
      Although rather delicate on account of their propensity to undergo deiodination, β-octaiodoporphyrinoids are of considerable interest as potential precursors to novel β-octasubstituted macrocycles. Presented herein are early results of our efforts to synthesize β-octaiodocorrole derivatives. Oxidative condensation of 3,4-diiodopyrrole and aromatic aldehydes failed to yield free-base octaiodocorroles. ...
    • Synthesis and molecular structure of perhalogenated rhenium-oxo corroles 

      Alemayehu, Abraham B.; Einrem, Rune F.; McCormick‑McPherson, Laura J.; Settineri, Nicholas S.; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)
      As part of our efforts to develop rhenium-oxo corroles as photosensitizers for oxygen sensing and photodynamic therapy, we investigated the potential <i>β</i>-perhalogenation of five ReO <i>meso</i>-tris(<i>para</i>-X-phenyl)corroles, Re[T<i>p</i>XPC](O) (X = CF<sub>3</sub>, H, F, CH<sub>3</sub>, and OCH<sub>3</sub>), with elemental chlorine and bromine. With Cl<sub>2</sub>, <i>β</i>-octachlorinated ...
    • Synthesis and structural studies of cyclic bioactive cysteine rich peptides 

      Sørum, Lisbeth (Mastergradsoppgave; Master thesis, 2009-05-20)
      Naturally occurring cyclic peptides have great therapeutic potential. Cyclotides are circular proteins found in the plants of the Rubiaceae, Violaceae and Cucurbitaceae families. They have an exceptional stability against chemical, enzymatic and thermal conditions due to their cyclic cystine knot (CCK) motif, which is the combination of a cyclic backbone and multiple disulfide bonds. In this thesis, ...
    • Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics 

      Simonovic, Danijela (Doctoral thesis; Doktorgradsavhandling, 2023-06-26)
      Effective antimicrobial drugs are the very core of modern medicine enabling successful prevention and treatment of infectious diseases. However, systemic misuse and overuse of antibiotics in human medicine, as well as in animal husbandry have led to widespread antibiotic-resistance, rendering many of these drugs ineffective. Therefore, there is an urgent need for new treatment options to conventional ...
    • Synthesis of 5,7-diarylindoles via Suzuki-Miyaura coupling in water 

      Elumalai, Vijayaragavan; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)
      The synthesis of novel 5,7-diaryl and diheteroaryl indoles has been explored via efficient double Suzuki–Miyaura coupling. The method notably employs a low catalyst loading of Pd(PPh<sub>3</sub>)<sub>4</sub> (1.5 mol%/coupling) and water as the reaction solvent to obtain 5,7-diarylated indoles without using N-protecting groups in up to 91% yield. The approach is also suitable for N-protected and ...
    • Synthesis of 5-,6-, and 7-membered heterocycles from barbituric acid derivatives 

      Guyader, David (Master thesis; Mastergradsoppgave, 2011-06-10)
      SUMMARY A new procedure has been developed for the synthesis of barbituric acid derivatives. The reactions were performed under solvent free conditions without any catalyst. Employing this synthetic route, a large number of chalconoids and 5-,6-, and 7-membered heterocycles have been successfully synthesized in a very short time. The chalconoids have been synthesized from a barbituric derivative ...
    • Synthesis of a novel class of antitubercular peptidomimetics based on β-aminoboronates. 

      Gorovoy, Alexey (Doctoral thesis; Doktorgradsavhandling, 2012-11-16)
      The unique properties of antimicrobial peptides have attracted the attention of chemists since the 1970’s. This class of compounds provides additional tools in the treatment of infections and the work described in this thesis was therefore focused on the synthesis of short peptidomimetics on the basis of modified amino acids and evaluation of their antimicrobial activity. The compounds of choice ...