English
norskBrowsing by Title
Now showing items 18173-18192 of 32932
-
LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-14)LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse models of cancer that typically resist current treatment options and to better understand the drug’s mode of action in vivo. We report LTX-315 mediates profound ... -
LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-10)LTX-315 is a nonameric oncolytic peptide in early clinical development for the treatment of solid malignancies. Preclinical and clinical evidence indicates that the anticancer properties of LTX-315 originate not only from its ability to selectively kill cancer cells, but also from its capacity to promote tumortargeting immune responses. Here, we investigated the therapeutic activity and immunological ... -
LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-08)The oncolytic peptide LTX-315, which has been <i>de novo</i> designed based on structure– activity relationship studies of host defense peptides, has the ability to kill human cancer cells and induce specific anticancer immune response when injected locally into tumors established in immunocompetent mice. The oncolytic effect of LTX-315 involves perturbation of plasma membrane and the mitochondria ... -
Luftambulansetjenesten HF. Hvert minutt bør telle. En studie av samvirke i praksis
(Master thesis; Mastergradsoppgave, 2017-06-06)Samvirkeprinsippet stiller krav til at alle beredskapsaktører har et selvstendig ansvar for å sikre best mulig samvirke (Meld. St. 29 (2011-2012), 2012). Luftambulansetjenesten er sentral for effektiv behandling, transport og beredskap ved akutt sykdom eller skade. Ambulanseflyene er alltid i beredskap og benyttes til oppdrag over hele landet. Dette krever et smidig beredskapsnettverk og effektiv ... -
Luftforsvarets offiserer – hvordan å motivere og beholde de. En studie om motivasjonens påvirkning på Luftforsvarets offiserer og deres militære karriere
(Master thesis; Mastergradsoppgave, 2023-11-28)En studie om motivasjonens påvirkning på Luftforsvarets offiserer og deres militære karriere. -
Luftfuktighet i bolighus
(Master thesis; Mastergradsoppgave, 2023-05-14)Denne masteroppgaven er en litteraturstudie av luftfuktighet i bolighus, i tillegg til en case studie i bolighus knyttet til luftfuktighet ved planter. Oppgaven dekker litteraturstudie knyttet til forskning og fakta både i Norge og internasjonalt. Ifølge verdens helseorganisasjon (WHO) oppholder en person seg 90 % av tiden innendørs. Luftfuktighet er en av faktorene som er avgjørende for at inneklima ... -
Luftkvalitet i kommunal arealplanlegging; En EØS-rettslig studie
(Doctoral thesis; Doktorgradsavhandling, 2024-04-12)<p>Luftkvalitet brukes som betegnelse på konsentrasjonene av forurensende stoffer i luften. Lokalt har luftkvaliteten stor påvirkning på menneskers helse og økosystemets bæreevne. Gjennom EØS-retten er Norge underlagt direktiver som pålegger myndighetene å ha kunnskaper om luftkvaliteten i landets syv geografiske soner til enhver tid. Myndighetene er også pålagt å skaffe seg kunnskaper om virkningen ... -
Luganokonvensjonen i Høyesterett - et kritisk blikk
(Chapter; Bokkapittel, 2018)Artikkelen drøfter Høyesteretts anvendelse av Luganokonvensjonen med særlig vekt på formuerettslige tvister og midlertidig sikring. Med utgangspunkt i konvensjonens formål og tolkningsprinsipper inntatt i konvensjonen kritiseres Høyesteretts bruk av konvensjonen i Trico -saken og Samsung-saken. Artikkelen tar også opp spørsmål knyttet til midlertidig sikring der partene har avtalt voldgift og den ... -
Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-01)The emergence of drug-resistant bacteria is increasing rapidly in all parts of the world, and the need for new antibiotics is urgent. In our continuous search for new antimicrobial molecules from under-investigated Arctic marine microorganisms, a marine fungus belonging to the family Lulworthiaceae (Lulworthiales, Sordariomycetes, and Ascomycota) was studied. The fungus was isolated from driftwood, ... -
Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-21)Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed—either from new chemical classes or drugs with new modes of action. Historically, natural products have been important contributors to drug discovery. In a recent study, the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family ... -
Lumbar total disc replacement: predictors for long-term outcome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-04)Purpose: We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). <br>Methods: We analysed a cohort of 82 patients with degenerative disc and chronic low back pain (LBP) who were treatedwith TDR and originally participated in a randomised trial comparing TDR and multidisciplinary rehabilitation. Potential predictors were ... -
Lumbosacral radiculopathy managed in multidisciplinary back clinics. Diagnostic accuracy, prognostic factors and efficacy of epidural injection therapy.
(Doctoral thesis; Doktorgradsavhandling, 2015-10-27)The accuracy of individual clinical index tests used to predict imaging findings of nerve root impingement in patients with chronic lumbar radiculopathy is low when applied in specialized care, but clinicians’ overall evaluation improves diagnostic accuracy slightly. The diagnostic accuracy of individual index tests was low with no tests reaching positive LR >4.0 or negative LR <0.4. The overall ... -
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-29)Aims Familial hypertrophic cardiomyopathy (HCM) is the most common form of inherited cardiac disease. It is characterized by myocardial hypertrophy and diastolic dysfunction, and can lead to severe heart failure, arrhythmias, and sudden cardiac death. Cardiac fibrosis, defined by excessive accumulation of extracellular matrix (ECM) components, is central to the pathophysiology of HCM. The ECM ... -
Lumikot: Fast auroral transients during the growth phase of substorms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-25)The development of a magnetospheric substorm may be classified into three phases: growth, expansion, and recovery. The growth phase is important as it includes processes that lead to the expansion. In a recent growth-phase study, a type of fast discrete auroral transient phenomena -- referred to as Lumikot -- were observed. The Lumikot are several kilometers across and move in the high-energy ... -
Luminescence characteristics of Scandinavian quartz, their connection to bedrock provenance and influence on dating results
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-23)The success of optically stimulated luminescence (OSL) dating relies to a large extent on suitable characteristics of the analysed mineral, in this case quartz. Previous OSL dating of Quaternary sediments in Scandinavia has shown that quartz characteristics vary widely across the region, resulting in dating studies with varied success. The aim of this study is to provide an overview of quartz ... -
Luminescence dating of holocene siliciclastic sediments in eastern Dahomey Basin, southwestern Nigeria
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)Several attempts at reconstructing geological settings and palaeoclimatic changes of the siliciclastic deposits of the Dahomey Basin, SW Nigeria, using relative age dating and correlation methods, have resulted in serious discrepancies on the ages. Therefore, a chronology framework established by an absolute age dating method is requisite to constrain the geological interpretation. This research ... -
Lumped, constrained cable modeling with explicit state-space formulation using an elastic version of Baumgarte stabilization
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-29)This paper presents a modeling approach for efficient simulation of slender structures, such as wires, cables and ropes. Lumped structural elements are connected using constraints. These are solved explicitly, using an elastic version of Baumgarte stabilization. This avoids singularities in the matrix inversions. The resulting explicit state-space formulation filters the higher order dynamics and ... -
Lumpsucker (Cyclopterus lumpus) otoliths: dissection, mounting and age-reading
(Research report; Forskningsrapport, 2000-05)A workshop was held at Institute of Marine Research, Flødevigen Marine Research Station, Arendal, Norway, 17-19 February 1999, to investigate methodes for age-determination of lumpsucker (Cyclopterus lumpus) from otoliths. The report summarises the results from the workshop and some subsequent analyses. The otoliths are very small and special training is necessary to locate them. The zonation pattern ... -
The Lunch effect. Can it result in biased grading at universities?
(Master thesis; Mastergradsoppgave, 2014-12-01)Examining exam results from an oral exam at a Norwegian university, reveals that there may be supporting evidence for the existence of a lunch-effect. Results suggests that censors are making the “easy” choices right before lunch, as compared with right after. The results are both a support to Danziger et al. (2011a) and to the existing literature on biased grading in general. -
Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-01)Background: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.<p><p>Methods: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 ...
