Artikler, rapporter og annet (klinisk medisin)

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Artikler, rapporter og annet (klinisk medisin)

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• Effect of Tailoring in an Internet-Based Intervention for Smoking Cessation: Randomized Controlled Trial

  Wangberg, Silje C; Nilsen, Olav; Antypas, Konstantinos; Gram, Inger Torhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

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  Abstract:

  Studies suggest that tailored materials are superior to nontailored materials in supporting health behavioral change. Several trials on tailored Internet-based interventions for smoking cessation have shown good effects. There have, however, been few attempts to isolate the effect of the tailoring component of an Internet-based intervention for smoking cessation and to compare it with the effectiveness of the other components. The study aim was to isolate the effect of tailored emails in an Internet-based intervention for smoking cessation by comparing two versions of the intervention, with and without tailored content. We conducted a two-arm, randomized controlled trial of the open and free Norwegian 12-month follow-up, fully automated Internet-based intervention for smoking cessation, slutta.no. We collected information online on demographics, smoking, self-efficacy, use of the website, and participant evaluation at enrollment and subsequently at 1, 3, and 12 months. Altogether, 2298 self-selected participants aged 16 years or older registered at the website between August 15, 2006 and December 7, 2007 and were randomly assigned to either a multicomponent, nontailored Internet-based intervention for smoking cessation (control) or a version of the same Internet-based intervention with tailored content delivered on the website and via email. Of the randomly assigned participants, 116 (of 419, response rate = 27.7%) in the intervention group and 128 (of 428, response rate = 29.9%) in the control group had participated over the 12 months and responded at the end of follow-up. The 7-day intention-to-treat abstinence rate at 1 month was 15.2% (149/982) among those receiving the tailored intervention, compared with 9.4% (94/999) among those who received the nontailored intervention (P < .001). The corresponding figures at 3 months were 13.5% (122/902) and 9.4% (84/896, P =.006) and at 12 months were 11.2% (47/419) and 11.7% (50/428, P = .91). Likewise, the intervention group had higher self-efficacy and perceived tailoring at 1 and 3 months. Self-efficacy was found to partially mediate the effect of the intervention. Tailoring an Internet-based intervention for smoking cessation seems to increase the success rates in the short term, but not in the long term.

  URI:

  http://hdl.handle.net/10037/3768

  File(s) in this item: 1

  article.pdf   (464.2Kb)
• Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia

  Acharya, Ganesh; Huhta, James; How, Ole-Jakob (Journal article; Tidsskriftartikkel, 2011)

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  URI:	http://hdl.handle.net/10037/3743

  File(s) in this item: 1

  article.pdf   (721.8Kb)
• The association of early post-transplant glucose levels with long term mortality

  Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

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  URI:	http://hdl.handle.net/10037/3741

  File(s) in this item: 1

  article.pdf   (207.5Kb)
• Flytting til byer fra distriktsområder med samisk bosetting

  Broderstad, Ann Ragnhild (Research report; Forskningsrapport, 2011)

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  Abstract:

  Senter for samisk helseforskning forbereder en survey i 2012 for personer som har flyttet fra samiske distriktsområder til byer. Undersøkelsen vil også omfatte barn av de som har flyttet. Som en innledende del ble det i samarbeid med NIBR gjennomført en registeranalyse. Denne rapporten gir noen resultater fra disse analysene. I første omgang var vi interessert i å undersøke hvor mange og hvor stor andel av de som hadde vokst opp i samiske områder som nå bor i en by, hvilke byer som peker seg ut, og hvordan variasjonene i flyttemønstrene for de ulike samiske områdene er. Vi valgte sju samiske kjerneområder i Nord-Norge bestående av til sammen 23 kommuner som utflyttingskommuner. By- kommunene det ble flyttet til er inndelt ti byer/bygrupper hvor alle de tradisjonelle byene i Norge er inkludert. Analysen omfatter 25 årskull, født 1950-74, altså de som var i alder 35-60 år. Av alle som hadde vokst opp i disse sju områdene bodde 36 prosent i en by i 2008. Siden surveyen også skulle omfatte barna til disse, inneholder rapporten også en analyse av fruktbarhetsnivå og barnetall for de som har flyttet til en by, til forskjell fra de som ikke har gjort det.

  URI:

  http://hdl.handle.net/10037/3722

  File(s) in this item: 1

  report.pdf   (1.694Mb)
• Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma

  Henriksen, Jørn Remi; Haug, Bjørn Helge; Büchner, Jochen; Tømte, Ellen; LØkke, cecilie; Flaegstad, Trond; Einvik, christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

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  Abstract:

  Background: Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggressive metastatic tumours with poor prognosis. Amplification of the MYCN oncogene is a well established poor prognostic factor found in up to 40% of high risk neuroblastomas. Using neuroblastoma cell lines to study neuronal differentiation in vitro is now well established. Several protocols, including exposure to various agents and growth factors, will differentiate neuroblastoma cell lines into neuron-like cells. These cells are characterized by a neuronal morphology with long extensively branched neurites and expression of several neurospecific markers. Results: In this study we use retrovirally delivered inducible short-hairpin RNA (shRNA) modules to knock down MYCN expression in MYCN-amplified (MNA) neuroblastoma cell lines. By addition of the inducer doxycycline, we show that the Kelly and SK-N-BE(2) neuroblastoma cell lines efficiently differentiate into neuron-like cells with an extensive network of neurites. These cells are further characterized by increased expression of the neuronal differentiation markers NFL and GAP43. In addition, we show that induced expression of retrovirally delivered anti- MYCN shRNA inhibits cell proliferation by increasing the fraction of MNA neuroblastoma cells in the G1 phase of the cell cycle and that the clonogenic growth potential of these cells was also dramatically reduced. Conclusion: We have developed an efficient MYCN-knockdown in vitro model system to study neuronal differentiation in MNA neuroblastomas.

  URI:

  http://hdl.handle.net/10037/3642

  File(s) in this item: 1

  article.pdf   (1.633Mb)

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