Ben-Batalla, Isabel; Cubas-Cordova, Miguel; Udonta, Florian; Wroblewski, Mark; Waizenegger, Jonas S.; Janning, Melanie; Sawall, Stefanie; Gensch, Victoria; Zhao, Lin; Martinez, Inigo Zubiavrre; Riecken, Kristoffer; Fehse, Boris; Pantel, Klaus; Bokemeyer, Carsten; Loges, Sonja (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
Anti-angiogenic therapies were approved for different cancers. However,
significant primary and secondary resistance hampers efficacy in several tumor types
including breast cancer. Thus, we need to develop clinically applicable strategies to
enhance efficacy of anti-angiogenic drugs.
We report that anti-angiogenic therapies can induce upregulation of
cyclooxygenase-2 (Cox-2) and of its product ...