Browsing by Author "Severi, Gianluca"

Now showing items 41-52 of 52

    • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study 

      Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill-Tove; Moi, Line; Muller, David; Aune, Dagfinn; Naccarati, Alessio; Panico, Salavatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay-Tee; Quirõs, Jose Ramõn; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
      Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...

    • Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations 

      Nimptsch, Katharina; Aleksandrova, Krasimira; Fedirko, Veronika; Jenab, Mazda; Gunter, Marc J.; Siersema, Peter D.; Wu, Kana; Katzke, Verena; Kaaks, Rudolf; Panico, Salvatore; Palli, Domenico; May, Anne M; Sieri, Sabina; Bueno-de-Mesquita, Bas; Olsen, Karina Standahl; Sánchez, Maria-Jose; Perez-Cornago, Aurora; Olsen, Anja; Tjønneland, Anne; Bonet, Catalina Bonet; Dahm, Christina C.; Chirlaque, María-Dolores; Fiano, Valentina; Tumino, Rosario; Gurrea, Aurelio Barricarte; Boutron-Ruault, Marie-Christine; Menegaux, Florence; Severi, Gianluca; van Guelpen, Bethany; Lee, Young-Ae; Pischon, Tobias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-24)
      <b><p>Background</b> The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. <b><p>Methods</b> We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on ...

    • Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition 

      Lin, Crystal; Travis, Ruth C.; Appleby, Paul N.; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger Torhild; Kaaks, Rudolf; Kiemeney, Lambertus A.; Ljungberg, Börje; Tumino, Rosario; Tjønneland, Anne; Roswall, Nina; Overvad, Kim; Boutron-Ruault, Marie-Christine; Manciniveri, Francesca Romana; Severi, Gianluca; Trichopoulou, Antonia; Masala, Giovanna; Sacerdote, Carlotta; Agnoli, Claudia; Panico, Salvatore; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Salamanca-Fernández, Elena; Chirlaque, Maria-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Menéndez, Virginia; Luján-Barroso, Leila; Liedberg, Fredrik; Freisling, Heinz; Gunter, Marc; Aune, Dagfinn; Cross, Amanda J.; Riboli, Elio; Key, Timothy J.; Perez-Cornago, Aurora (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-04)
      Previous <i>in vitro</i> and case–control studies have found an association between the insulin‐like growth factor (IGF)‐axis and bladder cancer risk. Circulating concentrations of IGF‐I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer has never been studied ...

    • Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts 

      Yang, Jae Jeong; Yu, Danxia; White, Emily; Lee, Dong Hoon; Blot, William; Robien, Kim; Park, Yikyung; Takata, Yumie; Gao, Yu-Tang; Smith-Byrne, Karl; Monninkhof, Evelyn M; Kaaks, Rudolf; Langhammer, Arnulf; Borch, Kristin Benjaminsen; Al-Shaar, Laila; Lan, Qing; Sørgjerd, Elin Pettersen; Zhang, Xuehong; Zhu, Clair; Chirlaque, María Dolores; Severi, Gianluca; Overvad, Kim; Sacerdote, Carlotta; Aune, Dagfinn; Johansson, Mattias; Smith-Warner, Stephanie A; Zheng, Wei; Shu, Xiao-Ou (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
      Background: Little is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations of prediagnosis leisuretime physical activity (LTPA) with all-cause and lung cancer–specific mortality among incident lung cancer patients. <p><p>Methods: Using self-reported data ...

    • Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma 

      Stepien, Magdalena; Lopez-Nogueroles, Marina; Lahoz, Agustın; Kühn, Tilman; Perlemuter, Gabriel; Voican, Cosmin; Ciocan, Dragos; Boutron-Ruault, Marie-Christine; Jansen, Eugéne H.J.M.; Viallon, Vivian; Leitzmann, Michael; Tjønneland, Anne; Severi, Gianluca; Mancini, Francesca Romana; Dong, Catherine; Kaaks, Rudolf; Fortner, Renée T.; Bergmann, Manuela M.; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Skeie, Guri; Merino, Susana; Zamora-Ros, Raúl; Sánchez, Maria Jose; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Sjöberg, Klas; Ohlsson, Bodil; Nyström, Hanna; Werner, Mårten; Perez-Cornago, Aurora; Schmidt, Julie A.; Freisling, Heinz; Scalbert, Augustin; Weiderpass, Elisabete; Christakoudi, Sofia; Gunter, Marc; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-29)
      Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of ...

    • Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations 

      Baker, Jacqueline Roshelli; Umesh, Sushma; Jenab, Mazda; Schomburg, Lutz; Tjønneland, Anne; Olsen, Anja; Marie-Christine, Boutron-Ruault; Rothwell, Joseph A.; Severi, Gianluca; Katzke, Verena; Johnson, Theron; Schulze, Matthias B.; Masala, Giovanna; Agnoli, Claudia; Simeon, Vittorio; Tumino, Rosario; Bueno-De-Mesquita, Bas; Gram, Inger Torhild; Skeie, Guri; Bonet, Catalina; RodrÍguez-Barranco, Miguel; Houerta, José María; Gylling, Björn; Van Guelpen, Bethany; Perez-Cornago, Aurora; Aglago, Elom; Freisling, Heinz; Weiderpass, Elisabete; Cross, Amanda J.; Heath, Alicia K.; Hughes, , David J.; Fedirko, Veronika (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-22)
      A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional ...

    • Prediagnostic calcium intake and lung cancer survival: A pooled analysis of 12 cohort studies 

      Yu, Danxia; Takata, Yumie; Smith-Warner, Stephanie A.; Blot, William; Sawada, Norie; White, Emily; Freedman, Neal; Robien, Kim; Giovannucci, Edward; Zhang, Xuehong; Park, Yikyung; Gao, Yu-Tang; Chlebowski, Rowan T.; Langhammer, Arnulf; Yang, Gong; Severi, Gianluca; Manjer, Jonas; Khaw, Kay-Tee; Weiderpass, Elisabete; Liao, Linda M.; Caporaso, Neil; Krokstad, Steinar; Hveem, Kristian; Sinha, Rashmi; Ziegler, Regina; Tsugane, Shoichiro; Xiang, Yong-Bing; Johansson, Mattias; Zheng, Wei; Shu, Xiao-Ou (Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-03-06)
      <p><i>Background</i>: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival.</p> <p><i>Methods</i>: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort ...

    • Prospective analysis of circulating metabolites and breast cancer in EPIC 

      His, Mathilde; Viallon, Vivian; Dossus, Laure; Gicquiau, Audrey; Achaintre, David; Scalbert, Augustin; Ferrari, Pietro; Romieu, Isabelle; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Dahm, Christina C.; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Fournier, Agnès; Rothwell, Joseph A.; Severi, Gianluca; Kühn, Tilman; Fortner, Renée Turzanski; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Martimianaki, Georgia; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; van Gils, Carla H.; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Skeie, Guri; Quirós, José Ramón; Agudo, Antonio; Sánchez, María-José; Amiano, Pilar; Huerta, José María; Ardanaz, Eva; Schmidt, Julie A.; Travis, Ruth C.; Riboli, Elio; Tsilidis, Konstantinos K.; Christakoudi, Sofia; Gunter, Mark J.; Rinaldi, Sabina (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
      <i>Background</i> - Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk.<p> <p><i>Methods</i> - A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which ...

    • Prospective analysis of circulating metabolites and endometrial cancer risk 

      Dossus, Laure; Kouloura, Eirini; Biessy, Carine; Viallon, Vivian; Siskos, Alexandros P.; Dimou, Niki; Rinaldi, Sabina; Merritt, Melissa A.; Allen, Naomi E.; Fortner, Renée T.; Kaaks, Rudolf; Weiderpass, Elisabete; Gram, Inger Torhild; Rothwell, Joseph A.; Lécuyer, Lucie; Severi, Gianluca; Schulze, Matthias B.; Nøst, Therese Haugdahl; Crous-Bou, Marta; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Barricarte, Aurelio; Schmidt, Julie A.; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Sacerdote, Carlotta; Mattiello, Amalia; Vermeulen, Roel; Heath, Alicia K.; Christakoudi, Sofia; Tsilidis, Konstantinos K.; Travis, Ruth C.; Gunter, Marc J.; Keun, Hector C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-05)
      Background. Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective ...

    • A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC 

      Papadimitriou, Nikos; Bouras, Emmanouil; van den Brandt, Piet A.; Muller, David C.; Papadopoulou, Areti; Heath, Alicia K.; Critselis, Elena; Gunter, Marc; Vineis, Paolo; Ferrari, Pietro; Weiderpass, Elisabete; Boeing, Heiner; Bastide, Nadia; Merritt, Melissa A.; Lopez, David S.; Bergmann, Manuela M.; Perez-Cornago, Aurora; Schulze, Matthias; Skeie, Guri; Srour, Bernard; Eriksen, Anne Kirstine; Boden, Stina; Johansson, Ingegerd; Nøst, Therese Haugdahl; Lukic, Marko; Ricceri, Fulvio; Ericson, Ulrika; Huerta, José-Maria; Dahm, Christina C.; Agnoli, Claudia; Amiano, Pilar; Tjønneland, Anne; Barricarte, Aurelio; Bueno-de-Mesquita, Bas; Ardanaz, Eva; Berntsson, Jonna; Sánchez, Maria-Jose; Tumino, Rosario; Panico, Salvatore; Katzke, Verena; Jakszyn, Paula; Masala, Giovanna; Derksen, Jeroen W.G.; Quirós, J. Ramón; Severi, Gianluca; Cross, Amanda J.; Riboli, Ellio; Tzoulaki, Ioanna; Tsilidis, Konstantinos K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-24)
      Background & Aims - Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk.<p> <p>Methods - The association ...

    • Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a 1 case-control study nested within a European prospective cohort 

      Aglago, Elom K.; Rinaldi, Sabina; Freisling, Heinz; Jiao, Li; Hughes, David J.; Fedirko, Veronika; Schalkwijk, Casper C; Weiderpass, Elisabete; Dahm, Christina C.; Overvad, Kim; Eriksen, Anne Kirstine; Kyrø, Cecilie; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Katzke, Verena; Kuhn, Tilman; Schulze, Matthias B.; Krasimira, Aleksandrova; Masala, Giovanna; Krogh, Vittorio; Panico, Salavatore; Tumino, Rosario; Naccarati, Alessio; Bueno-De-Mesquita, Bas; van Gils, Carla H.; Sandanger, Torkjel M; Gram, Inger Torhild; Skeie, Guri; Quiros, J. Ramon; Jakszyn, Rachel; Sanchez, Maria-Jose; Amiano, Pilar; Huerta, Jose Maria; Ardanaz, Eva; Johansson, Ingegerd; Harlid, Sophia; Perez-Cornago, Aurora; Mayén, Ana-Lucia; Cordova, Reynalda; Gunter, Marc J.; Vineis, Paolo; Cross, Amanda J.; Riboli, Elio; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-20)
      <p>Background: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. <p>Methods: To investigate whether sRAGE and related genetic variants are ...

    • Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms 

      Gagliardi, Amedeo; Dugué, Pierre-Antoine; Nøst, Therese Haugdahl; Southey, Melissa C.; Buchanan, Daniel D.; Schmidt, Daniel F; Makalic, Enes; Hodge, Allison M; English, Dallas R.; Wong Doo, Nicole; Hopper, John L.; Severi, Gianluca; Baglietto, Laura; Naccarati, Alessio; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Lund, Eiliv; Giles, Graham; Pardini, Barbara; Sandanger, Torkjel M; Milne, Roger L.; Paolo, Vineis; Polidoro, Silvia; Fiorito, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-11)
      <p>Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated. <p>Methods: A SEM, at a given CpG site, was defined as an extreme ...