Blar i forfatter "Ytrehus, Kirsti"

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    • The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection 

      Andreadou, Ioanna; Schulz, Rainer; Papapetropoulos, Andreas; Turan, Belma; Ytrehus, Kirsti; Ferdinandy, Peter; Daiber, Andreas; Di Lisa, Fabio (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-08)
      Redox signalling in mitochondria plays an important role in myocardial ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen species (ROS/RNS) modify cellular structures and functions by means of covalent changes in proteins including among others S‐nitros(yl)ation by nitric oxide (NO) and its derivatives, and S‐sulphydration by hydrogen sulphide (H<sub>2</sub>S). ...

    • Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture 

      Kuklin, Vladimir N.; Sovershaev, Mikhail; Andreasen, Thomas; Skogen, Vegard; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2005-10-18)
      Introduction: We recently demonstrated that the non-selective endothelin-1 (ET-1) receptor blocker tezosentan antagonizes ovine acute lung injury (ALI) following infusion of endotoxin or ET-1 by reducing the enhanced lung microvascular pressure, although we could not exclude the possibility of a simultaneous decline in microvascular permeability. In the present study, our aim was to find out if ...

    • Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C 

      Ingebretsen, Ole C.; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Sovershaev, Mikhail; Andreasen, Thomas; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2005-03-04)
      Introduction: Studies in vitro reveal that endothelin-1 (ET-1) activates the α isoform of protein kinase C (PKC-α) in cultures of endothelial cells, thereby deranging cellular integrity. Sepsis and endotoxemia are associated with increased plasma concentrations of ET-1 that induce acute lung injury (ALI). We recently reported that non-selective ET-1 receptor blockade attenuates ALI in sheep by ...

    • Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013 

      Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Storhaug, Hilde-Merete; Jenssen, Trond Geir; Eriksen, Bjørn Odvar; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-31)
      Aims: To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. <br>Methods and results: We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. End- points were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We strati fi ed the analyses ...