Blar i forfatter "Travis, Ruth C."

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    • Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study 

      Bamia, Christina; Lagiou, Pagona; Jenab, Mazda; Aleksandrova, Krasimira; Fedirko, Veronika; Trichopoulos, Dimitrios; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Katzke, Verena A.; Kühn, Tilman; Boeing, Heiner; Nöthlings, Ute; Palli, Domenico; Sieri, Sabina; Panico, Salvatore; Tumino, Rosaria; Naccarati, Allessio; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.M.; Weiderpass, Elisabete; Skeie, Guri; Quirós, José Ramón; Agudo, Antonio; Chirlaque, María-Dolores; Sánchez, María-José; Ardanaz, Eva; Dorronsoro, Miren; Ericson, Ulrika; Nilsson, Lena Maria; Wennberg, Maria; Khaw, Kay-Tee; Wareham, Nicholas J.; Key, Timothy J.; Travis, Ruth C.; Ferrari, Pietro; Stepien, Magdalena; Duarte-Salles, Talita; Norat, Teresa; Murphy, Neil; Riboli, Eilo; Trichopoulou, Antonia (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)
      Background: Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case–control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation ...

    • Genetic risk variants associated with in situ breast cancer 

      Campa, Daniele; Barrdahl, Myrto; Gaudet, Mia M.; Black, Amanda; Chanock, Stephen J.; Diver, W. Stephen; Gapstur, Susan M.; Haiman, Christopher; Hankinson, Susan; Hazra, Aditi; Henderson, Brian; Hoover, Robert N.; Hunter, David J.; Joshi, Amit; Kraft, Peter; Le Marchand, Loic; Lindström, Sara; Willett, Walter; Travis, Ruth C.; Amiano, Pilar; Siddiq, Afshan; Trichopoulos, Dimitrios; Sund, Malin; Tjønneland, Anne; Weiderpass, Elisabete; Peeters, Petra H.; Panico, Salvatore; Dossus, Laure; Ziegler, Regina G.; Canzian, Federico; Kaaks, Rudolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-13)
      Introduction: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered one of the strongest risk factors for BCIS.<p><p>Methods: To evaluate the association of BC susceptibility loci with BCIS risk, we genotyped 39 single nucleotide polymorphisms (SNPs), ...

    • Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Ward, Heather A; Whitman, Julia; Muller, David C; Johansson, Mattias; Jakszyn, Paula; Weiderpass, Elisabete; Palli, Domenico; Fanidi, Anouar; Vermeulen, Roel; Tjønneland, Anne; Hansen, Louise; Dahm, Christina C.; Overvad, Kim; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Affret, Aurélie; Kaaks, Rudolf; Fortner, Renee; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Kotanidou, Anastasia; Berrino, Franco; Krogh, Vittorio; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Quirós, José Ramón; Agudo, Antonio; Rodríguez-Barranco, Miguel; Larrañaga, Nerea; Huerta, Jose Maria; Ardanaz, Eva; Drake, Isabel; Brunnström, Hans; Johansson, Mikael; Grankvist, Kjell; Travis, Ruth C.; Freisling, Heinz; Stepien, Magdalena; Merritt, Melissa A.; Riboli, Elio; Cross, Amanda J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-18)
      <p><i>Background</i>: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential ...

    • Healthy lifestyle and the risk of pancreatic cancer in the EPIC study 

      Naudin, Sabine; Viallon, Vivian; Hashim, Dana; Freisling, Heinz; Jenab, Mazda; Weiderpass, Elisabete; Perrier, Flavie; McKenzie, Fiona; Bueno-de-Mesquita, Hendrik Bastiaan; Olsen, Anja; Tjønneland, Anne; Dahm, Christina C.; Overvad, Kim; Mancini, Francesca R.; Rebours, Vinciane; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kaaks, Rudolf; Bergmann, Manuela; Boeing, Heiner; Peppa, Eleni; Karakatsani, Anna; Trichopoulou, Antonia; Pala, Valeria; Masala, Giovana; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; May, Anne M.; van Gils, Carla H.; Rylander, Charlotta; Borch, Kristin Benjaminsen; Chirlaque López, María Dolores; Sánchez, Mariá-José; Ardanaz, Eva; Quirós, José Ramón; Amiano Exezarreta, Pilar; Sund, Malin; Drake, Isabel; Regnér, Sara; Travis, Ruth C.; Wareham, Nick; Aune, Dagfinn; Riboli, Elio; Gunter, Marc J.; Duell, Eric J.; Brennan, Paul; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-28)
      Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) ...

    • Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort 

      Ose, Jennifer; Fortner, Renée T; Schock, Helena; Peeters, Petra H.; Onland-Moret, N. Charlotte; Bueno-de-Mesquita, H. Bas; Weiderpass, Elisabete; Gram, Inger Torhild; Overvad, Kim; Tjønneland, Anne; Dossus, Laure; Fournier, Agnes; Baglietto, Laura; Trichopoulou, Antonia; Benetou, Vassiliki; Trichopoulos, Dimitrios; Boeing, Heiner; Masala, Giovanna; Krogh, Vittorio; Matiello, Amalia; Tumino, Rosaria; Popovic, Maja; Obón-Santacana, Mireia; Larrañaga, Nerea; Ardanaz, Eva; Sánchez, María-José; Menéndez, Virginia; Chirlaque, María-Dolores; Travis, Ruth C.; Khaw, Kay-Tee; Brändstedt, Jenny; Idahl, Annika; Lundin, Eva; Rinaldi, Sabina; Kuhn, Elisabetta; Romieu, Isabelle; Gunter, Marc J.; Merritt, Melissa A.; Riboli, Elio; Kaaks, Rudolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-04)
      Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.<p> <p>Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics ...

    • Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort 

      His, Mathilde; Viallon, Vivian; Dossus, Laure; Schmidt, Julie A.; Travis, Ruth C.; Gunter, Marc; Overvad, Kim; Kyrø, Cecilie; Tjønneland, Anne; Lécuyer, Lucie; Rothwell, Joseph A.; Severi, Gianluca; Johnson, Theron; Katzke, Verena; Schulze, Matthias B.; Masala, Giovanna; Sieri, Sabina; Panico, Salvatore; Tumino, Rosario; Macciotta, Alessandra; Boer, Jolanda M. A.; Monninkhof, Evelyn; Olsen, Karina Standahl; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Ardanaz, Eva; Vidman, Linda; Winkvist, Anna; Heath, Alicia K.; Weiderpass, Elisabete; Huybrechts, Inge; Rinaldi, Sabina (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)
      Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of ...

    • Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies 

      Jayasekara, Harindra; MacInnis, Robert J.; Lujan-Barroso, Leila; Mayen-Chacon, Ana-Lucia; Cross, Amanda J.; Wallner, Bengt; Palli, Domenico; Ricceri, Fulvio; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Kühn, Tilman; Kaaks, Rudolf; Tsilidis, Konstantinos K.; Sánchez, Maria-Jose; Amiano, Pilar; Ardanaz, Eva; Chirlaque López, María Dolores; Merino, Susana; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Sternby, Hanna; Sonestedt, Emily; Bueno-de-Mesquita, Bas; Boeing, Heiner; Travis, Ruth C.; Sandanger, Torkjel M; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Tjønneland, Anne; Yang, Yi; Hodge, Allison M.; Mitchell, Hazel; Haydon, Andrew; Room, R; Hopper, John L.; Weiderpass, Elisabete; Gunter, Marc J.; Riboli, Elio; Giles, Graham G.; Milne, Roger L.; Agudo, Antonio; English, Dallas R.; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-07)
      Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne ...

    • Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort 

      Molina-Montes, Esther; Sánchez, María-José; Buckland, Genevieve; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Amiano, Pilar; Wark, Petra A.; Kühn, Tilman; Katzke, Verena; Huerta, José María; Ardanaz, Eva; Quirós, José Ramón; Affret, Aurelie; His, Mathilde; Boutron-Ruault, Marie-Christine; Peeters, Petra H.; Ye, Weimin; Sund, Malin; Boeing, Heiner; Iqbal, Khalid; Ohlsson, Bodil; Sonestedt, Emily; Tjønneland, Anne; Petersen, Kristina E.N.; Travis, Ruth C.; Skeie, Guri; Agnoli, Claudia; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; Freisling, Heinz; Huybrechts, Inge; Overvad, Kim; Trichopoulou, Antonia; Bamia, Christina; Vasilopoulou, Effie; Wareham, Nick; Khaw, Kay-Tee; Cross, Amanda J.; Ward, Heather A.; Riboli, Elio; Duell, Eric J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
      Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. <br>Methods: Over half a million ...

    • Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia 

      Berndt, Sonja I.; Camp, Nicola J.; Skibola, Christine F.; Vijai, Joseph; Wang, Zhaoming; Gu, Jian; Nieters, Alexandra; Kelly, Rachel S; Smedby, Karin E.; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia S.; Lan, Qing; Teras, Lauren R; Machado, Moara; Yeager, Meredith; Brooks-Wilson, Angela R.; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda M.; Vajdic, Claire M.; Cocco, Pierluigi; Zhang, Yawei; Giles, Graham G.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Montalvan, Rebecca; Burdett, Laurie; Hutchinson, Amy; Ye, Yuanqing; Call, Timothy G.; Shanafelt, Tait D.; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Cunningham, Julie M.; Allmer, Cristine; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa A.; Diver, W Ryan; Link, Brian K.; Weiner, George J.; Conde, Lucia; Bracci, Paige M.; Riby, Jacques; Arnett, Donna K.; Zhi, Degui; Leach, Justin M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Sala, Nuria; Casabonne, Delphine; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Chaffee, Kari G.; Achenbach, Sara J.; Vachon, Celine M.; Goldin, Lynn R.; Strom, Sara S.; Leis, Jose F.; Weinberg, J. Brice; Caporaso, Neil E.; Norman, Aaron D.; De Roos, Anneclaire J.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Masala, Giovanna; Weiderpass, Elisabete; Chirlaque, Maria-Dolores; Vermeulen, Roel C.H.; Travis, Ruth C.; Southey, Melissa C.; Milne, Roger L.; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Clavel, Jacqueline; Zheng, Tongzhang; Holford, Theodore R.; Villano, Danylo J.; Maria, Ann; Spinelli, John J.; Gascoyne, Randy D.; Connors, Joseph M.; Bertrand, Kimberly A.; Giovannucci, Edward; Kraft, Peter; Kricker, Anne; Turner, Jenny; Ennas, Maria Grazia; Ferri, Giovanni M.; Miligi, Lucia; Liang, Liming; Ma, Baoshan; Huang, Jinyan; Crouch, Simon; Park, Ju-Hyun; Chatterjee, Nilanjan; North, Kari E.; Snowden, John A.; Wright, Josh; Fraumeni, Joseph F.; Offit, Kenneth; Wu, Xifeng; De Sanjose, Silvia; Cerhan, James R.; Chanock, Stephen J.; Rothman, Nathaniel; Slager, Susan L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-09)
      Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new ...

    • Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition 

      Kliemann, Nathalie; Viallon, Vivian; Murphy, Neil; Beeken, Rebecca J.; Rothwell, Joseph A.; Rinaldi, Sabina; Assi, Nada; van Roekel, Eline H.; Schmidt, Julie A.; Borch, Kristin Benjaminsen; Agnoli, Claudia; Rosendahl, Ann H.; Sartor, Hanna; Huerta, José María; Tjønneland, Anne; Halkjær, Jytte; Bueno-de-Mesquita, Bas; Gicquiau, Audrey; Achaintre, David; Aleksandrova, Krasimira; Schulze, Matthias B.; Heath, Alicia K.; Tsilidis, Konstantinos K.; Masala, Giovanna; Panico, Salvatore; Kaaks, Rudolf; Fortner, Renée T.; Van Guelpen, Bethany; Dossus, Laure; Scalbert, Augustin; Keun, Hector C.; Travis, Ruth C.; Jenab, Mazda; Johansson, Mattias; Ferrari, Pietro; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-30)
      Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.<p> <p>Methods: Targeted mass spectrometry ...

    • Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Campa, Daniele; Barrdahl, Myrto; Santoro, Aurelia; Severi, Gianluca; Baglietto, Laura; Omichessan, Hanane; Tumino, Rosario; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Weiderpass, Elisabete; Chirlaque, Maria-Dolores; Rodríguez-Barranco, Miguel; Agudo, Antonio; Gunter, Marc; Dossus, Laure; Krogh, Vittorio; Matullo, Giuseppe; Trichopoulou, Antonia; Travis, Ruth C.; Canzian, Federico; Kaaks, Rudolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-17)
      <p><i>Background</i>: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).</p> <p><i>Methods</i>: To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number ...

    • Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study 

      Muller, David C.; Murphy, Neil; Johansson, Mattias; Ferrari, Pietro; Tsilidis, Konstantinos K.; Boutron-Ruault, Marie-Christine; Clavel, Francoise; Dartois, Laureen; Li, Kuanrong; Kaaks, Rudolf; Weikert, Cornelia; Bergmann, Manuela; Boeing, Heiner; Tjønneland, Anne; Overvad, Kim; Redondo, María-Luisa; Agudo, Antonio; Molina-Portillo, Elena; Altzibar, Jone M.; Cirera, Lluis; Ardanaz, Eva; Khaw, Kay-Tee; Wareham, Nicholas J.; Key, Timothy J.; Travis, Ruth C.; Bamia, Christina; Orfanos, Philippos; Trichopoulou, Antonia; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Verschuren, W.M. Monique; Struijk, Ellen A.; Peeters, Petra H.; Engström, Gunnar; Melander, Olle; Sund, Malin; Weiderpass, Elisabete; Skeie, Guri; Lund, Eiliv; Norat, Teresa; Gunter, Marc; Riboli, Elio; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)
      Background<br> Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br> Methods<br> We analysed data from 264,906 European adults from the ...

    • A new pipeline for the normalization and pooling of metabolomics data 

      Viallon, Vivian; His, Mathilde; Rinaldi, Sabina; Breeur, Marie; Gicquiau, Audrey; Hémon, Bertrand; Overvad, Kim; Tjønneland, Anne; Rostgaard-Hansen, Agnetha Linn; Rothwell, Joseph A.; Lecuyer, Lucie; Severi, Gianluca; Kaaks, Rudolf; Johnson, Theron; Schulze, Matthias B.; Palli, Domenico; Agnoli, Claudia; Panico, Salvatore; Tumino, Rosaria; Ricceri, Fulvio; Monique Verschuren, Verschuren; Engelfriet, Peter; Onland-Moret, Charlotte; Vermeulen, Roel; Nøst, Therese Haugdahl; Urbarova, Ilona; Zamora-Ros, Raul; Rodríguez-Barranco, Miguel; Amiano, Pilar; Huerta, José María; Ardanaz, Eva; Melander, Olle; Ottoson, Filip; Vidman, Linda; Rentoft, Matilda; Schmidt, Julie A.; Travis, Ruth C.; Weiderpass, Elisabete; Johansson, Mattias; Dossus, Laure; Jenab, Mazda; Gunter, Marc; Bermejo, Justo Lorenzo; Scherer, Dominique; Salek, Reza M.; Keski-Rahkonen, Pekka; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-17)

    • Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium 

      Fortner, Renée T.; Poole, Elizabeth M.; Wentzensen, Nicolas A.; Trabert, Britton; White, Emily; Arslan, Alan A.; Patel, Alpa V.; Setiawan, V. Wendy; Visvanathan, Kala; Weiderpass, Elisabete; Adami, Hans Olov; Black, Amanda; Bernstein, Leslie; Brinton, Louise A.; Buring, Julie; Clendenen, Tess V.; Fournier, Agnès; Fraser, Gary; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Gram, Inger Torhild; Hartge, Patricia; Hoffman-Bolton, Judith; Idahl, Annika; Kaaks, Rudolf; Kirsh, Victoria A.; Knutsen, Synnøve; Koh, Woon-Puay; Lacey, James V.; Lee, I-Min; Lundin, Eva; Merritt, Melissa A.; Milne, Roger L.; Onland-Moret, N. Charlotte; Peters, Ulrike; Poynter, Jenny N.; Rinaldi, Sabina; Robien, Kim; Rohan, Thomas; Sánchez, María-José; Schairer, Catherine; Schouten, Leo J.; Tjønneland, Anne; Townsend, Mary K.; Travis, Ruth C.; Trichopoulou, Antonia; van den Brandt, Piet A.; Vineis, Paolo; Wilkens, Lynne; Wolk, Alicja; Yang, Hannah P.; Zeleniuch-Jacquotte, Anne; Tworoger, Shelley S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-18)

    • Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition 

      Breeur, Marie; Ferrari, Pietro; Dossus, Laure; Jenab, Mazda; Johansson, Mattias; Rinaldi, Sabina; Travis, Ruth C.; His, Mathilde; Key, Tim J.; Schmidt, Julie A.; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Rothwell, Joseph A.; Laouali, Nasser; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Eichelmann, Fabian; Palli, Domenico; Grioni, Sara; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Olsen, Karina Standahl; Sandanger, Torkjel M; Nøst, Therese Haugdahl; Quirós, J. Ramón; Bonet, Catalina; Barranco, Miguel Rodríguez; Chirlaque, María-Dolores; Ardanaz, Eva; Sandsveden, Malte; Manjer, Jonas; Vidman, Linda; Rentoft, Matilda; Muller, David; Tsilidis, Kostas; Heath, Alicia K.; Keun, Hector; Adamski, Jerzy; Keski-Rahkonen, Pekka; Scalbert, Augustin; Gunter, Marc J.; Viallon, Vivian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-19)
      Background - Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.<p> <p>Methods - We analysed targeted metabolomics ...

    • Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer 

      Kyrø, Cecilie; Olsen, Anja; Landberg, Rikard; Skeie, Guri; Loft, Steffen; Åman, Per; Leenders, Max; Dik, Vincent K.; Siersema, Peter D.; Pischon, Tobias; Christensen, Jane; Overvad, Kim; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Cottet, Vanessa; Kühn, Tilman; Chang-Claude, Jenny; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; Trichopoulos, Dimitrios; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Peeters, Petra H.; Weiderpass, Elisabete; Bakken, Toril; Åsli, Lene Angell; Arguelles, Marcial; Jakszyn, Paula; Sánchez, Maria-Jose; Amiano, Pilar; Huerta, Jose Maria; Barricarte, Aurelio; Ljuslinder, Ingrid; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J; Travis, Ruth C.; Ferrari, Pietro; Freisling, Heinz; Jenab, Mazda; Gunter, Marc J; Murphy, Neil; Riboli, Elio; Tjønneland, Anne; Bueno-de-Mesquita, H. Bas (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-12-07)
      Background<p> <p>Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.<p> <p>Methods <p>The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal ...

    • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study 

      Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill-Tove; Moi, Line; Muller, David; Aune, Dagfinn; Naccarati, Alessio; Panico, Salavatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay-Tee; Quirõs, Jose Ramõn; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
      Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...

    • Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium 

      Ose, Jennifer; Schock, Helena; Poole, Elizabeth M.; Lehtinen, Matti; Visvanathan, Kala; Helzlsouer, Kathy; Buring, Julie E.; Lee, I-Min; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Trichopoulou, Antonia; Mattiello, Amalia; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Sánchez, María-José; Idahl, Annika; Travis, Ruth C.; Rinaldi, Sabina; Merritt, Melissa A.; Wentzensen, Nicolas; Tworoger, Shelley S.; Kaaks, Rudolf; Fortner, Renée T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
      Purpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results.<br> Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer ...

    • Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition 

      Lin, Crystal; Travis, Ruth C.; Appleby, Paul N.; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger Torhild; Kaaks, Rudolf; Kiemeney, Lambertus A.; Ljungberg, Börje; Tumino, Rosario; Tjønneland, Anne; Roswall, Nina; Overvad, Kim; Boutron-Ruault, Marie-Christine; Manciniveri, Francesca Romana; Severi, Gianluca; Trichopoulou, Antonia; Masala, Giovanna; Sacerdote, Carlotta; Agnoli, Claudia; Panico, Salvatore; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Salamanca-Fernández, Elena; Chirlaque, Maria-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Menéndez, Virginia; Luján-Barroso, Leila; Liedberg, Fredrik; Freisling, Heinz; Gunter, Marc; Aune, Dagfinn; Cross, Amanda J.; Riboli, Elio; Key, Timothy J.; Perez-Cornago, Aurora (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-04)
      Previous <i>in vitro</i> and case–control studies have found an association between the insulin‐like growth factor (IGF)‐axis and bladder cancer risk. Circulating concentrations of IGF‐I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer has never been studied ...

    • Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition 

      Perez-Cornago, Aurora; Appleby, Paul N.; Tipper, Sarah; Key, Timothy J.; Allen, Naomi E.; Nieters, Alexandra; Vermeulen, Roel; Roulland, Sandrine; Casabonne, Delphine; Kaaks, Rudolf; Fortner, Renée T.; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Klinaki, Eleni; Hansen, Louise; Tjønneland, Anne; Bonnet, Fabrice; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Pala, Valeria; Masala, Giovanna; Sacerdote, Carlotta; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Dorronsoro, Miren; Quirós, J. Ramón; Barricarte, Aurelio; Gavrila, Diana; Agudo, Antonio; Borgquist, Signe; Rosendahl, Ann H.; Melin, Beatrice; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Riboli, Elio; Vineis, Paolo; Travis, Ruth C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-27)
      Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls ...