Browsing by Author "Småbrekke, Lars"
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Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-14)In recent years, low dose naltrexone (LDN) has been used as an off-label therapy for several chronic diseases. Results from small laboratory and clinical studies indicate some beneficial effects of LDN in autoimmune diseases, but clinical research on LDN in rheumatic disease is limited. Using a pharmacoepidemiological approach, we wanted to test the hypothesis that starting LDN leads to reduced ... -
Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study
von Hanno, Therese; Hareide, Live Lund; Småbrekke, Lars; Morseth, Bente; Sneve, Monica; Erke, Maja Gran; Mathiesen, Ellisiv B.; Bertelsen, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-12)PURPOSE. The purpose of this study was to investigate associations between cardiovascular risk factors and the thickness of retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and outer retina layers (ORL).<p> <p>METHODS. In this population-based study, we included participants from the Tromsø Study: Tromsø6 (2007 to 2008) and Tromsø7 (2015 to 2016). Persons with ... -
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)<i>Background</i> - Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism.<p> <p><i>Methods</i> - We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. ... -
Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study
Gravningen, Kirsten Midttun; Field, Nigel; Blix, Hege Salvesen; Asfeldt, anne mette; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)<i>Background</i> - Non-prescription purchase of antibiotics is undesirable and has not recently been investigated in a representative population in a high-income low-use country during travel abroad. This study examined self-reported prevalence of antibiotic purchase abroad with and without prescription among participants reporting international travel in a general adult population in Norway, and ... -
The Norwegian Society for Pharmacoepidemiology
Lupattelli, Angela; Karlstad, Øystein; Engeland, Anders; Småbrekke, Lars; Olsen, Kristine; Øvrebust, Aina; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)The Norwegian Society for Pharmacoepidemiology (NFFE) is a multidisciplinary, nation-wide network of professionals involved in the field of pharmacoepidemiology. Pharmacoepidemiology is the science that bridges epidemiologic methodology with clinical pharmacology and clinical pharmacy, for studying the use, effectiveness, value and safety of pharmaceuticals1 . The foundation of NFFE took into ... -
Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
Haldorsen, Bjørg; Giske, Christian G; Hansen, Dennis S; Helgason, Kristjan Orri; Kahlmeter, Gunnar; Löhr, Iren Høyland; Matuschek, Erika; Österblad, Monica; Rantakokko-Jalava, Kaisu; Wang, Mikala; Småbrekke, Lars; Samuelsen, Ørjan; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)Objectives: To examine performance of EUCAST disc diffusion and supplementary MIC methods for detection of Enterobacteriaceae with reduced susceptibility to meropenem using EUCAST screening recommendations.<p> <p>Methods: Sixty-one Nordic laboratories delivered data on EUCAST disc diffusion (n " 61), semi-automated meropenem MIC (n " 23; VITEK2, n " 20 and Phoenix, n " 3) and gradient meropenem ... -
A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences
Garcia, Beate Hennie; Storli, Sissel Lisa; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado]
Garcia, Beate Hennie; Giverhaug, Trude; Høgli, June U.; Skjold, Frode; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06)OBJECTIVES: The aim of the study was twofold; 1) to develop a clinical pharmacist-led 12 month lasting follow-up program for patients with established coronary heart disease (CHD) discharged from the University Hospital of North Norway, and 2) to explore the impact of the program with regards to adherence to a medication assessment tool for secondary prevention of CHD and change in biomedical ... -
Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug resistance (MDR) in <i>Escherichia coli</i>. In this study, we evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) indices of fosfomycin and its <i>in vivo</i> activity in an experimental murine model of ascending UTI. Subcutaneous administration of fosfomycin showed that ... -
Self-reported medication information needs among medication users in a general population aged 40 years and above – the Tromsø study
Walquist, Mari Johannessen; Svendsen, Kristian; Garcia, Beate Hennie; Bergmo, Trine Strand; Eggen, Anne Elise; Halvorsen, Kjell H.; Småbrekke, Lars; Ringberg, Unni; Lehnbom, Elin; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)Purpose: To determine the prevalence and associated factors of self-reported medication information needs among medication users in a general population aged 40 years and above – The Tromsø Study.<p> <p>Methods: Cross-sectional study of medication users (n=10,231) among participants in the Tromsø Study, a descriptive analysis of questionnaire data and multivariable logistic regression (n=9,194). Results: ... -
Social network analysis of Staphylococcus aureus carriage in a general youth population
Stensen, Dina Benedicte Berg; Cañadas, Rafael A. Nozal; Småbrekke, Lars; Olsen, Karina; Nielsen, Christopher Sivert; Svendsen, Kristian; Hanssen, Anne Merethe; Ericson, Johanna U; Simonsen, Gunnar Skov; Bongo, Lars Ailo; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-31)Objectives Staphylococcus aureus carriage increases infection risk. We used social network analysis to evaluate whether contacts have the same S. aureus genotype indicating direct transmission, or whether contagiousness is an indirect effect of contacts sharing the same lifestyle or characteristics. Methods The Fit Futures 1 study collected data on social contact among 1038 high school students. ... -
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-26)Purpose: Following a TV documentary in 2013, there was a tremendous increase in low dose naltrexone (LDN) use in a wide range of unapproved indications in Norway. We aim to describe the extent of this sudden and unprecedented increase in LDN prescribing, to characterize patients and LDN prescribers, and to estimate LDN dose sizes.<br> Methods: LDN prescriptions recorded in the Norwegian Prescription ... -
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
Robinson, Eirin Guldsten; Gyllensten, Hanna; Johansen, Jeanette Schultz; Havnes, Kjerstin; Granås, Anne Gerd; Bergmo, Trine Strand; Småbrekke, Lars; Garcia, Beate Hennie; Halvorsen, Kjell Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)Background - Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management model is an interdisciplinary method aiming to optimize medication therapy and improve patient outcomes.<p> <p>Objective - We aimed to investigate the cost effectiveness of a medication optimization intervention compared to standard care in acutely hospitalized older ...