English
norskBlar i forfatter "Sørbye, Sveinung Wergeland"
Viser treff 21-40 av 40
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Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)BACKGROUND: Prognostic markers in curable STS may have the potential to guide therapy after surgical resection. The purpose of this study was to clarify the prognostic impact of the presence of cells and growth factors belonging to the innate immune system in soft tissue sarcomas (STS). The significance of macrophages (CD68), their growth factor macrophage colony-stimulating factor (M-CSF), its ... -
Prognostic Impact of Jab1, p16, p21, p62, Ki67 and Skp2 in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Purpose The purpose of this study is to clarify the prognostic significance of expression of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas (STS). Optimised treatment of STS requires better identification of high risk patients who will benefit from adjuvant therapy. The prognostic significance of Jab1, p16, p21, p62, Ki67 and Skp2 in STS has not been sufficiently investigated. ... -
Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting ... -
Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)In recent years, microRNAs (miRNAs) have been found to play an essential role in tumor development. In lung tumorigenesis, targets and pathways of miRNAs are being revealed, and further translational research in this field is warranted. MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 ... -
Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)BACKGROUND: The purpose of this study was to clarify the prognostic significance of peritumoral lymphocyte infiltration in the capsule of soft tissue sarcomas (STS). Multiple observations in preclinical and clinical studies have shown that the immune system has a role in controlling tumor growth and progression. Prognostic markers in potentially curable STS should guide therapy after surgical ... -
Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)BACKGROUND: S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant ... -
The Prognostic Impact of TGF-beta 1, Fascin, NF-kappa B and PKC-zeta Expression in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Transforming growth factor-β (TGF-β), fascin, nuclear factor-kappa B (NF-κB) p105, protein-kinase C-zeta (PKC-ζ), partioning-defective protein-6 (Par-6), E-cadherin and vimentin are tumor promoting molecules through mechanisms involved in cell dedifferentiation. In soft tissue sarcomas, their expression profile is poorly defined and their significance is uncertain. We aimed to investigate the ... -
Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIFregulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from206 patients with non-GIST STS were obtained and tissue microarrays were constructed. ... -
Prognostic value of adaptive and innate immune system in soft tissue sarcomas
(Doctoral thesis; Doktorgradsavhandling, 2013-09-26)The purpose of this study was to clarify the prognostic significance of the adaptive and innate immune system in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has ... -
Prognostic value of the MicroRNA regulators dicer and drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-11)Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. We have investigated the prognostic impact of Dicer and Drosha and their correlation with miR-126 expression in a large cohort of non-small cell lung cancer (NSCLC) patients. We aimed to find ... -
A rapid chemokine response of macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and the regulated on activation, normal T expressed and secreted chemokine is associated with a sustained virological response in the treatment of chronic hepatitis C
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The role of chemokines in chronic hepatitis C virus (HCV) infection is not fully understood. The present study aimed to characterize the baseline serum concentrations and the initial β-chemokine response to treatment with interferon-α and ribavirin with respect to the final clinical outcome of virological response to treatment. Serum concentrations of alanine aminotransferase (ALT) and of the CC ... -
Real-life evaluation of histologic scores for Ulcerative Colitis in remission
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-08)Background - Histological evaluation of ulcerative colitis (UC) patients has been debated ever since the first description of the disease and its role in follow-up has never been fully established. Recent evidence suggests an added benefit in accuracy when evaluating if the patient is in remission. Unfortunately, there are several different histological indices, and it is difficult to compare outcomes ... -
Redegjør for HPV-resultater
(Chronicle; Kronikk, 2011-01-25)Fire Tromsø-leger tilbakeviser kritikk fra Bergen-professor om at de har oversolgt resultater fra sin studie om HPV-testing. De redegjør for hvordan de har fulgt opp kvinner med usikre celleforandringer. -
Risk of cervical intraepithelial neoplasia grade 3 or higher (CIN3+) among women with HPV-test in 1990–1992, a 30-year follow-up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-22)<i>Background/objective</i> - Having a 30-year follow-up of a cohort of women tested for HPV is a unique opportunity to further study long-term risk of CIN3+. The study objective was to compare HPV status at baseline with the risk of CIN3+ in the follow-up period of 30 years.<br><br> <i>Methods</i> - All women (n = 642) referred to the HPV outpatient clinic at the University Hospital of North ... -
Støtter dansk HPV-praksis
(Chronicle; Kronikk, 2012-02-13)Danskene har en fornuftig praksis når kvinner med lette celleforandringer blir undersøkt med en spesifikk HPV mRNA test i stedet for umiddelbar kolposkopi og biopsi. -
Triage of women with ASC-US/LSIL cytology: The added value of implementation of an HPV-test
(Conference object; Konferansebidrag, 2013)This study has an historical prospective design by including in retrospect all screening- and follow-up tests for women aged 25 to 69 years old kept by the Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø. All women with a first ASC-US/LSIL smear in 1996-98 and 2006-08 were identified and compared on outcomes such as proportion of cases resolved within 35 months of ... -
Triage of Women with Low-Grade Cervical Lesions : HPV mRNA Testing versus Repeat Cytology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)In Norway, women with low-grade squamous intraepithelial lesions (LSIL) are followed up after six months in order to decide whether they should undergo further follow-up or be referred back to the screening interval of three years. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures. At the University ... -
Triage of Women with Minor Cervical Lesions : Data Suggesting a "Test and Treat" Approach for HPV E6/E7 mRNA Testing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Vaksine og screening : ja takk, begge deler!
(Journal article; Tidsskriftartikkel, 2010-01-21)- I Norge trenger vi ikke velge mellom HPV-vaksine eller screening. Vi har råd til begge deler. -
The VEGF- and PDGF-family of angiogenic markers have prognostic impact in soft tissue sarcomas arising in the extremities and trunk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Background: Soft-tissue sarcomas are rare malignant tumors of mesenchymal lineage that can arise in any part of the body. Prognosis, and hence also treatment may vary according to histologic subtype and localization. Angiogenesis is the process of forming new blood vessels from pre-existing ones. The deregulation of this process is thought to be an important step in malignant transformation. This ...
