Blar i forfatter "Njølstad, Inger"

Viser treff 21-40 av 103

    • Cohort profile: The Tromsø Study 

      Jacobsen, Bjarne Koster; Eggen, Anne Elise; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The Tromsø Study was initiated in 1974 in an attempt to help combat the high mortality of cardiovascular diseases in Norway, that was particularly pronounced among middle-aged men. In the mid-1970s, Norwegian men had a 20% risk of dying of myocardial infarction (MI) before the age of 75 years. The situation in Northern Norway was even worse.1 The primary aim of the Tromsø Study was to determine ...

    • Comparative effectiveness of antihypertensive medication of primary prevention of cardiovascular disease : systematic review and multiple treatments meta-analysis 

      Fretheim, Atle; Odgaard-Jensen, Jan; Brørs, Odd; Madsen, Steinar; Njølstad, Inger; Norheim, Ole Frithjof; Svilaas, Arne B; Thürmer, Hanne; Flottorp, Signe (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We conducted a systematic review of evidence from randomized controlled trials to answer the following research question: What are the relative effects of different classes of antihypertensive drugs in reducing the incidence of cardiovascular disease outcomes for healthy people at risk of cardiovascular disease? We searched MEDLINE, EMBASE, AMED (up to February 2011) and CENTRAL (up to May 2009), ...

    • Complex lifestyle intervention among inactive older adults with elevated cardiovascular disease risk and obesity: a mixed-method, single-arm feasibility study for RESTART—a randomized controlled trial 

      Deraas, Trygve Sigvart; Hopstock, Laila Arnesdatter; Henriksen, André; Morseth, Bente; Sand, Anne-Sofie; Njølstad, Inger; Pedersen, Sigurd; Sagelv, Edvard Hamnvik; Johansson, Jonas; Grimsgaard, Sameline (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-27)
      Background - Physical inactivity and obesity are global public health challenges. Older adults are important to target for prevention and management of disease and chronic conditions. However, many individuals struggle with maintaining increased physical activity (PA) and improved diet. This feasibility study provides the foundation for the RESTART trial, a randomized controlled trial (RCT) to test ...

    • Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses 

      Varmdal, Torunn; Løchen, Maja-Lisa; Wilsgaard, Tom; Njølstad, Inger; Nyrnes, Audhild; Grimsgaard, Sameline; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-14)
      Aim: To assess whether stroke diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for the Tromsø Study, a population-based epidemiological study.<p> <p>Method: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as the gold standard, we calculated correctness (defined as positive predictive value, PPV) and ...

    • Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979–2012 

      Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-08)
      The data presented in this article relate to the research article entitled “Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979–2012” (Albrektsen et al., 2017) [1]. Data quantify the gender differences in the risk of myocardial infarction (MI) in terms of incidence rate ratios (IRR), in subgroups defined by serum lipids, ...

    • Dialog og refleksjon. Festskrift til Tom Andersens 60 års dag 

      Anderson, Harlene; Flåm, Anna Margrethe; Talberg, Pål; Forsdahl, Anders; Gergen, Kenneth. J.; Hartviksen, Ivar; Hoffman, Lynn; Høyer, Georg; Kjellberg, Eva; Korvald, Erik; kristiansen, Unni; Lebenbaum, Peter; Lindseth, Anders; McNamee, Sheila; Mjøs, Ole. D.; Penn, Peggy; Reichelt, Ebbe. G.; Reichelt, Sissel; Seikkula, Jaakko; Aaltonen, Jukka; Alakare, Birgitta; Shotter, John; Katz, Arlene M.; Stensland, Per; Søgaard, Anne Johanne; Fønnebø, Vinjar; Wagner, Judith; Wifstad, Åge; Øverberg, Gudrun; Aaraas, Ivar; Njølstad, Inger (Research report; Forskningsrapport, 1996)

    • Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts 

      Aspelund, Thor; Grübler, Martin R.; Smith, Albert V.; Gudmundsson, Elias F.; Keppel, Martin; Cotch, Mary Frances; Harris, Tamara B.; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grove-Laugesen, Diana; Rejnmark, Lars; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan; Gudnason, Vilmundur; Eiríksdóttir, Gudny (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)
      The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...

    • Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromso OGTT Study 

      Hutchinson, Moira Strand; Joakimsen, Ragnar Martin; Njølstad, Inger; Schirmer, Henrik; Figenschau, Yngve Anton; Svartberg, Johan; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Hb 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by Hb and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. Hb , fasting ...

    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...

    • Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism - The Tromsø Study 

      Lind, Caroline; Enga, Kristin Fjeldstad; Mathiesen, Ellisiv B.; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Females display lower risk of myocardial infarction from higher estimated cardiorespiratory fitness than males. The Tromsø Study 1994-2014 

      Sagelv, Edvard Hamnvik; Casolo, Andrea; Eggen, Anne Elise; Heitmann, Kim Arne; Johansen, Kristoffer Robin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Morseth, Bente; Njølstad, Inger; Osborne, John Owen; Hagerupsen, Karianne; Pedersen, Sigurd; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-06)
      Objective - To examine the dose-response association between estimated cardiorespiratory fitness (eCRF) and risk of myocardial infarction (MI).<p> <p>Patients and Methods - Adults who attended Tromsø Study surveys 4-6 (Janurary 1,1994-December 20, 2008) with no previous cardiovascular disease were followed up through December 31, 2014 for incident MI. Associations were examined using restricted ...

    • Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability 

      Sanna, S; Li, BS; Mulas, A; Sidore, C; Kang, HM; Jackson, AU; Piras, MG; Usala, G; Maninchedda, G; Sassu, A; Serra, F; Palmas, MA; Wood, WH; Njølstad, Inger; Laakso, M; Hveem, Kristian; Tuomilehto, J; Lakka, TA; Rauramaa, R; Boehnke, M; Cucca, F; Uda, M; Schlessinger, D; Nagaraja, R; Abecasis, GR (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Complex trait genome-wide association studies (GWAS) provide an efficient strategy for evaluating large numbers of common variants in large numbers of individuals and for identifying trait-associated variants. Nevertheless, GWAS often leave much of the trait heritability unexplained. We hypothesized that some of this unexplained heritability might be due to common and rare variants that reside in ...

    • Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels 

      Parikh, H; Wang, ZM; Pettigrew, KA; Jia, JP; Daugherty, S; Yeager, M; Jacobs, KB; Hutchinson, A; Burdett, L; Cullen, M; Qi, LQ; Boland, J; Collins, I; Albert, TJ; Vatten, Lars Johan; Hveem, Kristian; Njølstad, Inger; Cancel-Tassin, G; Cussenot, O; Valeri, A; Virtamo, J; Thun, MJ; Feigelson, HS; Diver, WR; Chatterjee, N; Thomas, G; Albanes, D; Chanock, SJ; Hunter, DJ; Hoover, R; Hayes, RB; Berndt, SI; Sampson, J; Amundadottir, L (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have been shown to be associated with both serum PSA levels and prostate cancer. Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine ...

    • Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study 

      Zostautiene, Leva; Jorde, Rolf; Schirmer, Henrik; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Kamycheva, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
      Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor ...

    • A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium 

      McKay, James D.; Truong, Therese; Gaborieau, V; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, G; Zaridze, D; Shangina, O; Szeszenia-Dabrowska, N; Lissowska, Jolanta; Rudnai, P; Fabianova, E; Bucur, A; Bencko, V; Holcatova, I; Janout, V; Foretova, L; Lagiou, Pagona; Trichopoulos, Dimitrios; Benhamou, S; Ahrens, Wolfgang; Bouchardy, C; Merletti, F; Richiardi, L; Talamini, R; Simonato, L; Barzan, L; Kjærheim, Kristina; Macfarlane, G; Agudo, Antonio; Macfarlane, Tatiana V.; Canova, C; Castellsague, X; Conway, DI; Lowry, R; Healy, CM; McKinney, PA; Toner, ME; Znaor, A; Menezes, A; Curado, MP; Koifman, S; Neto, JE; Wünsch-Filho, V; Boccia, S; Arzani, D; Garrote, LF; Cadoni, G; Olshan, AF; Weissler, MC; Luo, JC; Funkhouser, WK; Lubinski, Jan; Lener, M; Trubicka, J; Schwartz, SM; Oszutowska, D; Doody, DR; Chen, C; Fish, S; Lazarus, P; Muscat, JE; Gallagher, CJ; Zhang, Zuo-Feng; Chang, SC; Wei, QY; Sturgis, EM; Franceschi, S; Kelsey, KT; Wang, LE; Herrero, R; Marsit, CJ; McClean, MD; Romkes, M; Nelson, HH; Buch, S; Nukui, T; Zhong, SL; Lacko, M; Manni, JJ; McLaughlin, J; Hung, RJ; Peters, WHM; Vatten, Lars Johan; Njølstad, Inger; Goodman, GE; Field, JK; Palli, D; Liloglou, T; Clavel-Chapelon, F; Vineis, P; Krogh, V; Tumino, R; Panico, S; Martinez, Carmen; Gonzalez, CA; Quiros, JR; Navarro, C; Larranaga, N; Khaw, KT; Ardanaz, E; Key, T; Peeters, PHM; Bueno-De-Mesquita, H. Bas; Boeing, H; Overvad, K; Trichopoulou, A; Linseisen, J; Hallmans, G; Tjønneland, Anne; Riboli, Elio; Kumle, Merethe; Valk, K; Voodern, Tonu; Metspalu, Andres; Boland, A; Zelenika, D; Delepine, M; Foglio, M; Lechner, D; Blanché, Hélène; Gut, Ivo G.; Galan, P; Hashibe, Mia; Heath, Simon; Hayes, Richard B.; Lathrop, Mark; Boffetta, Paolo; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and ...

    • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification 

      Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Mägi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, Ηe; Εvangelou, Εvangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Müller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Corrêa, Ivan R.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, André G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir Lingaas; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Inês; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njølstad, Inger; Wichmann, H.-Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josée; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
      Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without ...

    • HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confoundersin a meta-analysis of individual participant data from six cohort studies 

      Schöttker, Ben; Rathmann, Wolfgang; Herder, Christian; Thorand, Barbara; Wilsgaard, Tom; Njølstad, Inger; Siganos, Galatios; Mathiesen, Ellisiv B.; Saum, Kai-Uwe; Peasey, Anne; Feskens, Edith J.M.; Boffetta, Paolo; Trichopoulou, Antonia; Kuulasmaa, Kari; Kee, Frank; Brenner, Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-11)
      Background:<br>To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations.<br> Methods:<br> The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six ...

    • Health in overweight children: 2-year follow-up of Finnmark Activity School-a randomised trial 

      Kokkvoll, Ane Sofie; Grimsgaard, Sameline; Steinsbekk, Silje; Flægstad, Trond; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-20)

    • Hematocrit and risk of venous thromboembolism in a general population. The Tromso study 

      Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • High prevalence of overweight and obesity among 6-year-old children in Finnmark County, North Norway 

      Kokkvoll, Ane Sofie; Jeppesen, Elisabeth; Juliusson, Petur Benedikt; Flægstad, Trond; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)