Blar i forfatter "Nielsen, Erik Waage"

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    • Lactate gap: a diagnostic support in severe metabolic acidosis of unknown origin 

      Hauvik, Linn Eva; Varghese, Mercy; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)
      Ethylene glycol poisoning is a medical emergency. The metabolites glycolate and glyoxylate give metabolic acidosis. Because of similar structure, these metabolites are misinterpreted as lactate by many point-of-care blood gas analyzers. The falsely high lactate values can lead to misdiagnosis, inappropriate laparotomies, and delayed antidotal therapy. As laboratory analyzers measure plasma lactate ...

    • Metabolic alkalosis is the most common acid-base disorder in ICU patients 

      Mæhle, Kirsten Vikesland; Haug, Bjørn; Flaatten, Hans; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-28)

    • Nine out of ten trauma calls to a Norwegian hospital are avoidable: a retrospective analysis 

      Stordahl, Harald; Passas, Eva; Hopland, Andreas; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-03)
      Background: Our aim was to estimate the degree of overtriage (Injury Severity Score [ISS] ≤ 15) of trauma call patients in Nordland Hospital Bodø, Norway. We also determined the transportation time from injury to hospital admission. Methods: We used data from our Acute Medical Information System, ambulance records and patient charts relating to ISS and estimation of response and transport times. ...

    • A Novel Porcine Model of Ischemia-Reperfusion Injury After Cross-Clamping the Thoracic Aorta Revealed Substantial Cardiopulmonary, Thromboinflammatory and Biochemical Changes Without Effect of C1-Inhibitor Treatment 

      Nielsen, Erik Waage; Miller, Yoav; Brekke, Ole Lars; Grond, Joost; Duong, Anh Hoang; Fure, Hilde; Ludviksen, Judith K; Pettersen, Kristin; Reubsaet, Leon; Solberg, Rigmor; Johansen, Harald Thidemann; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Ischemic injury worsens upon return of blood and innate immunity including the complement system play a central role in ischemia-reperfusion injury (IRI) as in thoracic aortic surgery. Complement component1 inhibitor (C1-INH) has been shown to reduce IRI and is a broad-acting plasma cascade inhibitor. We established a new porcine model of IRI by cross-clamping the thoracic aorta and evaluated the ...

    • Open chest and pericardium facilitate transpulmonary passage of venous air emboli 

      Storm, Benjamin; Halvorsen, Per Steinar; Skulstad, Helge; Dybwik, Knut Gustav; Schjalm, Camilla; Christiansen, Dorte; Wisløff-Aase, Kristin; Fosse, Erik; Braaten, Tonje Bjørndal; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-17)
      <p><i>Background:</i> Transpulmonary passage of air emboli can lead to fatal brain- and myocardial infarctions. We studied whether pigs with open chest and pericardium had a greater transpulmonary passage of venous air emboli than pigs with closed thorax. <p><i>Methods:</i> We allocated pigs with verified closed foramen ovale to venous air infusion with either open chest with sternotomy and opening ...

    • Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14 

      Skjeflo, Espen Waage; Christiansen, Dorte; Landsem, Anne; Stenvik, Jørgen; Woodruff, T. M.; Espevik, Terje; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
      <i>Background</i> - Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in human whole blood.<p> <p><i>Methods</i> - Lepirudin-anticoagulated blood was incubated with live or dead <i>E. coli</i> or <i>S. aureus</i> at 37 °C for 120 min ...

    • Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity: Evidence from bariatric surgery 

      Trøseid, Marius; Nestvold, Torunn Kristin; Rudi, Knut; Thoresen, Hanna; Nielsen, Erik Waage; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-15)
      OBJECTIVE It is of vital importance to elucidate the triggering factors of obesity and type 2 diabetes to improve patient care. Bariatric surgery has been shown to prevent and even cure diabetes, but the mechanism is unknown. Elevated levels of lipopolysaccharide (LPS) predict incident diabetes, but the sources of LPS are not clarified. The objective of the current study was to evaluate the ...

    • Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model 

      Pischke, Søren; Hestenes, Siv Merete; Johansen, Harald Thidemann; Fure, Hilde; Bugge, Jan F; Espinoza, Andreas Westenvik; Skulstad, Helge; Edvardsen, Thor; Fosse, Erik; Mollnes, Tom Eirik; Halvorsen, Per Steinar; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-27)
      <i>Introduction</i> - Right ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood. Pulmonary artery hypertension (PAH) plays a part in the pathogenesis of the right heart dysfunction in sepsis but its importance is unknown. In pigs, PAH in sepsis is substantial and the translational value of porcine sepsis models ...

    • Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation 

      Skjeflo, Espen Waage; Christiansen, Dorte; Fure, Hilde; Ludviksen, Judith K; Woodruff, Trent M.; Espevik, Terje; Nielsen, Erik Waage; Brekke, Ole-Lars; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-13)
      <p><i>Background - </i>There is extensive cross‐talk between the complement system, the Toll‐like receptors (TLRs), and hemostasis. Consumptive coagulopathy is a hallmark of sepsis, and is often mediated through increased tissue factor (TF) expression. <p><i>Objectives - </i>To study the relative roles of complement, TLRs and TF in <i>Staphylococcus aureus</i>‐induced coagulation. <p><i>Methods - ...

    • A successful new method for single left lobe recruitment 

      Dybwik, Knut Gustav; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-18)
      Any gas will flow down the path of least resistance and highest compliance. This is a problem in the treatment of severe unilateral lung disease in the intensive care unit (ICU). Deep sedation interferes with the diaphragm’s ability to distribute air into the lower lung. Spontaneous breathing in a conscious patient, in combination with mechanical ventilation via an endotracheal tube inserted into ...

    • Unexplained severe lactic acidosis in emergency medicine 

      Ulvin, Ole Erik; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-20)
      Case report A 49-year-old previously healthy man was admitted to the ICU after cardiac arrest following a short history with headache, blurred speech and reduced consciousness. After cardiopulmonary resuscitation perfusion rhythm was regained, but the patient didn`t regain consciousness. The arterial blood gas analysis at the ICU revealed a severe metabolic acidosis with pH at 6.86 and lactate ...

    • Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs 

      Storm, Benjamin; Ludviksen, Judith K; Christiansen, Dorte; Fure, Hilde; Pettersen, Kristin; Landsem, Anne; Nilsen, Bent Aksel; Dybwik, Knut Gustav; Braaten, Tonje; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      Introduction: Air embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood. Since these findings have not been verified in vivo, we aimed to examine the effects of air embolism in pigs on thromboinflammation.<p> <p>Methods: Forty-five landrace pigs, average 17 kg (range 8.5-30), ...

    • Why does the provision of home mechanical ventilation vary so widely? 

      Dybwik, Knut; Tollåli, Terje; Nielsen, Erik Waage; Brinchmann, Berit Støre (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      There is wide variation in the provision of home mechanical ventilation (HMV) throughout Europe, but the provision of home mechanical ventilation can also vary within countries. In 2008, the overall prevalence of HMV in Norway was 19.9/100,000, and there were huge regional differences in treatment prevalence. The aim of this study is to find explanations for these differences. We gathered ...

    • A young man with acute dilated cardiomyopathy associated with methylphenidate. 

      Nymark, Tor Bjarne; Hovland, Anders W.; Bjørnstad, Hanne; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel, 2008)
      An 18-year-old obese man with a body mass index of 40, diagnosed with attention-defi cit hyperactivity disorder and treated with methylphenidate (Concerta®) was acutely admitted to hospital with hypoxia and dyspnoea. On investigation signs of liver-, renal-, and heart-failure were found. Noradrenalin infusion was started. Echocardiography showed dilated left ventricle and an ejection fraction (EF) ...