Blar i forfatter "Murphy, Neil"

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    • Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: A multinational cohort study 

      Murphy, Neil; Ward, Heather A.; Jenab, Mazda; Rothwell, Joseph A.; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Kvaskoff, Marina; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Weiderpass, Elisabete; Skeie, Guri; Borch, Kristin Benjaminsen; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Dahm, Christina C.; Jakszyn, Paula; Sánchez, María-José; Gil, Leire; Huerta, José María; Barricarte, Aurelio; Quirós, José Ramón; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn E.; Trichopoulou, Antonia; La Vecchia, Carlo; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno-de-Mesquita, Hendrik Bastiaan; Peeters, Petra H.M.; Gylling, Björn; Myte, Robin; Jirström, Karin; Berntsson, Jonna; Xue, Xiaonan; Riboli, Elio; Cross, Amanda J.; Gunter, Mark J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)
      <i>Background & Aims</i> - Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision.<p><p> <i>Methods</i> - In the European Prospective Investigation ...

    • Menstrual factors, reproductive history, hormone use, and urothelial carcinoma risk: A prospective study in the EPIC cohort 

      Lujan-Barroso, Leila; Botteri, Edoardo; Caini, Saverio; Ljungberg, Börje; Roswall, Nina; Tjønneland, Anne; Bueno-De-Mesquita, Bas; Gram, Inger Torhild; Tumino, Rosario; Kiemeney, Lambertus A.; Liedberg, Fredrik; Stocks, Tanja; Gunter, Marc; Murphy, Neil; Cervenka, Iris; Fournier, Agnès; Kvaskoff, Marina; Häggström, Christel; Overvad, Kim; Lund, Eiliv; Waaseth, Marit; Fortner, Renée T.; Kühn, Tilman; Menéndez, Virginia; Sánchez, María-José; Santiuste, Carmen; Perez-Cornago, Aurora; Zamora-Ros, Raul; Cross, Amanda J.; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Krogh, Vittorio; Sciannameo, Veronica; Mattiello, Amalia; Panico, Salvatore; van Gils, Carla H.; Onland-Moret, N. Charlotte; Barricarte, Aurelio; Amiano, Pilar; Khaw, Kay-Tee; Boeing, Heiner; Weiderpass, Elisabete; Duell, Eric J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-28)
      <p>Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. <p>Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and ...

    • Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition 

      Kliemann, Nathalie; Viallon, Vivian; Murphy, Neil; Beeken, Rebecca J.; Rothwell, Joseph A.; Rinaldi, Sabina; Assi, Nada; van Roekel, Eline H.; Schmidt, Julie A.; Borch, Kristin Benjaminsen; Agnoli, Claudia; Rosendahl, Ann H.; Sartor, Hanna; Huerta, José María; Tjønneland, Anne; Halkjær, Jytte; Bueno-de-Mesquita, Bas; Gicquiau, Audrey; Achaintre, David; Aleksandrova, Krasimira; Schulze, Matthias B.; Heath, Alicia K.; Tsilidis, Konstantinos K.; Masala, Giovanna; Panico, Salvatore; Kaaks, Rudolf; Fortner, Renée T.; Van Guelpen, Bethany; Dossus, Laure; Scalbert, Augustin; Keun, Hector C.; Travis, Ruth C.; Jenab, Mazda; Johansson, Mattias; Ferrari, Pietro; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-30)
      Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.<p> <p>Methods: Targeted mass spectrometry ...

    • Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Kliemann, Nathalie; Ammar, Romain Ould; Biessy, Carine; Gicquiau, Audrey; Katzke, Verena; Kaaks, Rudolf; Tjønneland, Anne; Olsen, Anja; Sánchez, Maria-Jose; Crous-Bou, Marta; Pasanisi, Fabrizio; Tin, Sandar Tin; Perez-Cornago, Aurora; Aune, Dagfinn; Christakoudi, Sofia; Heath, Alicia K.; Colorado-Yohar, Sandra M.; Grioni, Sara; Skeie, Guri; Sartor, Hanna; Idahl, Annika; Rylander, Charlotta; May, Anne M.; Weiderpass, Elisabete; Freisling, Heinz; Playdon, Mary C.; Rinaldi, Sabina; Murphy, Neil; Huybrechts, Inge; Dossus, Laure; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)
      Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known.<p> <p>Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case–control study (817 cases/ 817 controls) within the European Prospective Investigation ...

    • Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study 

      Muller, David C.; Murphy, Neil; Johansson, Mattias; Ferrari, Pietro; Tsilidis, Konstantinos K.; Boutron-Ruault, Marie-Christine; Clavel, Francoise; Dartois, Laureen; Li, Kuanrong; Kaaks, Rudolf; Weikert, Cornelia; Bergmann, Manuela; Boeing, Heiner; Tjønneland, Anne; Overvad, Kim; Redondo, María-Luisa; Agudo, Antonio; Molina-Portillo, Elena; Altzibar, Jone M.; Cirera, Lluis; Ardanaz, Eva; Khaw, Kay-Tee; Wareham, Nicholas J.; Key, Timothy J.; Travis, Ruth C.; Bamia, Christina; Orfanos, Philippos; Trichopoulou, Antonia; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Verschuren, W.M. Monique; Struijk, Ellen A.; Peeters, Petra H.; Engström, Gunnar; Melander, Olle; Sund, Malin; Weiderpass, Elisabete; Skeie, Guri; Lund, Eiliv; Norat, Teresa; Gunter, Marc; Riboli, Elio; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)
      Background<br> Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br> Methods<br> We analysed data from 264,906 European adults from the ...

    • A Nested Case–Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Murphy, Neil; Cross, Amanda J; Abubakar, Mustapha; Jenab, Mazda; Aleksandrova, Krasmira; Boutron-Ruault, Marie-Christine; Dossus, Laure; Racine, Antoine; Kühn, Tilman; Katzke, Verena A.; Tjønneland, Anne; Petersen, Kristina E N; Overvad, Kim; Quiros, J Ramon; Jakszyn, Paula; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José-Maria; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nick; Travis, Ruth C; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Siersema, Peter D; Peeters, Petra H; Ohlsson, Bodil; Ericson, Ulrika; Palmqvist, Richard; Nyström, Hanna; Weiderpass, Elisabete; Skeie, Guri; Freisling, Heinz; Kong, So Yeon; Tsilidis, Kostas; Muller, David C; Riboli, Eilo; Gunter, Marc J (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-05)
      Background:<br> Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. ...

    • Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study 

      Deschasaux, Mélanie; Huybrechts, Inge; Murphy, Neil; Julia, Chantal; Hercberg, Serge; Srour, Bernard; Kesse-Guyot, Emmanuelle; Latino-Martel, Paule; Biessy, Carine; Casagrande, Corinne; Jenab, Mazda; Ward, Heather; Weiderpass, Elisabete; Dahm, Christina C.; Overvad, Kim; Kyrø, Cecilie; Olsen, Anja; Affret, Aurélie; Boutron-Ruault, Marie-Christine; Mahamat-Saleh, Yahya; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Schwingshackl, Lukas; Bamia, Christina; Peppa, Eleni; Trichopoulou, Antonia; Masala, Giovanna; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Hjartåker, Anette; Rylander, Charlotta; Skeie, Guri; Ramõn Quirõs, Jose; Jakszyn, Paula; Salamanca-Fernández, Elena; Huerta, José María; Ardanaz, Eva; Amiano, Pilar; Ericson, Ulrika; Sonestedt, Emily; Huseinovic, Ena; Johansson, Ingegerd; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn E.; Perez-Cornago, Aurora; Tsilidis, Konstantinos K.; Ferrari, Pietro; Riboli, Elio; Gunter, Mark J.; Touvier, Mathilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-18)
      <p><i>Background - </i>Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of a simplified labelling system to reflect the nutritional quality of food products. The Nutri-Score, a five-colour nutrition label, is derived from the Nutrient Profiling System of the British ...

    • Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer 

      Kyrø, Cecilie; Olsen, Anja; Landberg, Rikard; Skeie, Guri; Loft, Steffen; Åman, Per; Leenders, Max; Dik, Vincent K.; Siersema, Peter D.; Pischon, Tobias; Christensen, Jane; Overvad, Kim; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Cottet, Vanessa; Kühn, Tilman; Chang-Claude, Jenny; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; Trichopoulos, Dimitrios; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Peeters, Petra H.; Weiderpass, Elisabete; Bakken, Toril; Åsli, Lene Angell; Arguelles, Marcial; Jakszyn, Paula; Sánchez, Maria-Jose; Amiano, Pilar; Huerta, Jose Maria; Barricarte, Aurelio; Ljuslinder, Ingrid; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J; Travis, Ruth C.; Ferrari, Pietro; Freisling, Heinz; Jenab, Mazda; Gunter, Marc J; Murphy, Neil; Riboli, Elio; Tjønneland, Anne; Bueno-de-Mesquita, H. Bas (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-12-07)
      Background<p> <p>Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.<p> <p>Methods <p>The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal ...

    • Plasma concentrations of persistent organic pollutants and pancreatic cancer risk 

      Porta, Miquel; Gasull, Magda; Pumarega, José; Kiviranta, Hannu; Rantakokko, Panu; Raaschou-Nielsen, Ole; Bergdahl, Ingvar A.; Sandanger, Torkjel M; Agudo, Antoni; Rylander, Charlotta; Nøst, Therese Haugdahl; Donat-Vargas, Carolina; Aune, Dagfinn; Heath, Alicia K; Cirera, Lluís; Goni-Irigoyen, Fernando; Alguacil, Juan; Giménez-Robert, Álex; Tjønneland, Anne; Sund, Malin; Overvad, Kim; Romana Mancini, Francesca; Rebours, Vinciane; Boutron-Ruault, Marie Christine; Kaaks, Rudolf; Schulze, Matthias B.; Trichopoulou, Antonia; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Vermeulen, Roel; Ramón Quirós, J; Rodríguez-Barranco, Miguel; Colorado-Yohar, Sandra M.; Chirlaque, María Dolores; Ardanaz, Eva; Wareham, Nick; Key, Tim; Johansson, Mattias; Murphy, Neil; Ferrari, Pietro; Huybrechts, Inge; Chajes, Veronique; Gonzalez, Carlos Alberto; de Mesquita, Bas Bueno; Gunter, Marc; Vainio, Elisabete Weiderpass; Riboli, Elio; Duell, Eric J; Katzke, Verena; Vineis, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)
      Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.<p> Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched ...

    • Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: A cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Harms, Laura; Scalbert, Augustin; Zamora-Ros, Raul; Rinaldi, Sabina; Jenab, Mazda; Murphy, Neil; Achaintre, David; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Romana, Mancini; Mahamat-Saleh, Yahya; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Katzke, Verena; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Palli, Domenico; Panico, Salvatore; Sieri, Sabina; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Hendrik Bastian; Vermeulen, Roel; Weiderpass, Elisabete; Nøst, Therese Haugdahl; Lasheras, Cristina; RodrÍguez-Barranco, Miguel; Huerta, José María; Barricarte, Aurelio; Dorronsoro, Miren; Hultdin, Johan; Schmidt, Julie A.; Gunter, Marc; Riboli, Elio; Aleksandrova, Krasimira (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-04)
      Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation ...

    • Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition 

      Ward, Heather A.; Norat, Teresa; Overvad, Kim; Dahm, Christina C.; Bueno-de-Mesquita, H. Bas; Jenab, Mazda; Fedirko, Veronika; van Duijnhoven, Fränzel J.B.; Skeie, Guri; Romaguera-Bosch, Dora; Tjønneland, Anne; Olsen, Anja; Carbonnel, Franck; Affret, Aurélie; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kühn, Tilman; Aleksandrova, Krassimira; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Bamia, Christina; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Naccarati, Alessio; Mattiello, Amalia; Peeters, Petra H.M.; Weiderpass, Elisabete; Åsli, Lene Angell; Jakszyn, Paula; Ramõn Quirõs, Jose; Sánchez, María-José; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Jirström, Karin; Ericson, Ulrika; Johansson, Ingegerd; Gylling, Björn; Bradbury, Kathryn E.; Khaw, Kay-Tee; Wareham, Nicholas J.; Stepien, Magdalena; Freisling, Heinz; Murphy, Neil; Cross, Amanda J.; Riboli, Elio (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-19)

    • Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study 

      Merritt, Melissa A.; Riboli, Elio; Murphy, Neil; Kadi, Mai; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Dossus, Laure; Dartois, Laureen; Clavel-Chapelon, Françoise; Fortner, Renée T.; Katzke, Verena A.; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Lund, Eiliv; Nakamura, Aurelie; Weiderpass, Elisabete; Quirós, José Ramón; Agudo, Antonio; Molina-Montes, Esther; Larranaga, Nerea; Dorronsoro, Miren; Cirera, Lluis; Barricarte, Aurelio; Olsson, Åsa; Butt, Salma; Idahl, Annika; Lundin, Eva; Wareham, Nicholas J.; Key, Timothy J.; Brennan, Paul; Ferrari, Pietro; Wark, Petra A.; Norat, Teresa; Cross, Amanda J.; Gunter, Mark J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-30)
      Background: Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. <p>Methods: The analysis was performed within the European Investigation into Cancer and Nutrition ...

    • Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations 

      Fedirko, Veronika; Mandle, Hannah B.; Zhu, Wanzhe; Hughes, David J.; Siddiq, Afshan; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Bueno-de-Mesquita, Hendrik Bastiaan; van Duijnhoven, Fränzel J.B.; Siersema, Peter D.; Tjønneland, Anne; Olsen, Anja; Perduca, Vittorio; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Johnson, Theron; Krasimira, Aleksandrova; Trichopoulou, Antonia; Makrythanasis, Periklis; Thanos, Dimitris; Panico, Salvatore; Krogh, Vittorio; Sacerdote, Carlotta; Skeie, Guri; Weiderpass, Elisabete; Colorado-Yohar, Sandra; Sala, Núria; Barricarte, Aurelio; Sánchez, María-José; Quirós, Ramón; Amiano, Pilar; Gylling, Björn; Harlid, Sophia; Perez-Cornago, Aurora; Heath, Alicia K.; Tsilidis, Konstantinos K.; Aune, Dagfinn; Freisling, Heinz; Murphy, Neil; Gunter, Marc J.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-20)
      Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, ...