Blar i forfatter "Hindberg, Kristian"

Viser treff 21-35 av 35

    • Nytt legemiddel for å hindre tilbakefall av blodpropp? 

      Hindberg, Kristian (Others; Andre, 2015-11-27)
      I en ny studie, utført i flere europeiske land, er det undersøkt om legemiddelet Sulodexide kan forebygge at man får en ny blodpropp etter å først ha fått én. Etter at man har fått en blodpropp vil man få behandling med blodfortynnende medisin. For noen pasienter er dessverre risikoen for indre blødninger for stor med denne behandlingen, og behandlingen blir derfor avsluttet etter 3-12 måneder. Det ...

    • Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism 

      Hansen, Ellen-Sofie; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)
      Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE and explored the potential of a causal association ...

    • Plasma levels of leptin and risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-11)
      Background - Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain.<p> <p>Objective - This article investigates the association between ...

    • Plasma levels of mannose-binding lectin and future risk of venous thromboembolism 

      Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Garred, Peter; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
      <i>Background</i> - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular ...

    • Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism 

      Edvardsen, Magnus; Hindberg, Kristian; Hansen, Ellen-Sofie; Morelli, Vania Maris; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Holtet Evensen, Line; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)
      Several case-control studies have reported elevated plasma von Willebrand factor (VWF) levels in patients with venous thromboembolism (VTE) compared with controls. However, because few studies have investigated the association in a prospective design, it is unclear whether elevated plasma VWF is a risk factor or a consequence of the VTE event. Therefore, we aimed to investigate the prospective ...

    • Plasma lipopolysaccharide-binding protein is a biomarker for future venous thromboembolism: Results from discovery and validation studies 

      Jensen, Søren Beck; Latysheva, Nadezhda; Hindberg, Kristian; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background<p> <p>Effect-size underestimation impedes biomarker identification. Long follow-up time in prospective studies attenuates effect-size estimates for transient biomarkers, while disease category–specific biomarkers are affected by merging of categories. Venous thromboembolism (VTE) encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE). <p>Objectives <p>(i) To re-analyze untargeted ...

    • Plasma procoagulant phospholipid clotting time and venous thromboembolism risk 

      Ramberg, Cathrine; Wilsgård, line; Latysheva, Nadezhda; Brækkan, Sigrid Kufaas; Hindberg, Kristian; Sovershaev, Timofey; Snir, Omri; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
      Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL<sub>CT</sub>) and future risk of venous thromboembolism (VTE).<p> <p>Objectives - To investigate the ...

    • Prothrombotic genotypes and risk of major bleeding in patients with incident venous thromboembolism 

      Johnsen, Håkon Sandbukt; Bjøri, Esben; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-22)
      <i>Background</i> - Genotypes associated with venous thromboembolism (VTE) may protect against bleeding due to a hypercoagulable state. Whether the risk of major bleeding is reduced in parallel with an increasing number of prothrombotic genotypes during anticoagulant treatment in VTE remains unknown.<p> <p><i>Objectives</i> - To investigate the association between multiple prothrombotic genotypes ...

    • Prothrombotic genotypes and risk of venous thromboembolism in occult cancer 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Severinsen, Marianne T.; Gabrielsen, Maiken Elvestad; Kristensen, Søren R.; Næss, Inger Anne; Hindberg, Kristian; Tjønneland, Anne; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
      Background - Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) affect VTE risk in occult cancer have not been addressed. The aim of this study was to investigate the joint effect of five prothrombotic genotypes and occult ...

    • Repeated assessments of physical activity and risk of incident venous thromboembolism 

      Evensen, Line Holtet; Isaksen, Trond; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
      <p><i>Background</i>: Whether physical activity influences the risk of incident venous thromboembolism (VTE) remains controversial, potentially because of methodological challenges, such as regression dilution bias.</p> <p><i>Objectives</i>: To investigate whether physical activity was associated with VTE risk, and explore the role of body mass index (BMI) as a mediator in a population‐based ...

    • Rewarming From Hypothermic Cardiac Arrest Applying Extracorporeal Life Support: A Systematic Review and Meta-Analysis 

      Bjertnæs, Lars J.; Hindberg, Kristian; Næsheim, Torvind; Suborov, Evgeny V.; Reierth, Eirik; Kirov, Mikhail Y.; Lebedinskii, Konstantin M.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-13)
      <i>Introduction</i>: This systematic review and meta-analysis aims at comparing outcomes of rewarming after accidental hypothermic cardiac arrest (HCA) with cardiopulmonary bypass (CPB) or/and extracorporeal membrane oxygenation (ECMO).<br><br> <i>Material and Methods</i>: Literature searches were limited to references with an abstract in English, French or German. Additionally, we searched ...

    • The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study 

      Morelli, Vania Maris; Sejrup, Joakim Knutsen; Småbrekke, Birgit; Rinde, Ludvig B; Grimnes, Gro; Isaksen, Trond; Hansen, John-Bjarne; Hindberg, Kristian; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
      Stroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. ...

    • Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial 

      Ramberg, Cathrine; Hindberg, Kristian; Biedermann, Joseph S.; Cannegieter, Suzanne C.; van der Meer, Felix J.; Snir, Omri; Leebeek, Frank W. G.; Kruip, Marieke J. H. A.; Hansen, John Bjarne; Lijfering, Willem M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-25)
      Background - Venous thromboembolism (VTE) is a frequent cardiovascular disease with severe complications, including recurrence and death. There is a great need for alternative prophylactic treatment options as anticoagulation is accompanied by increased bleeding risk. Statins are reported to reduce the risk of incident and recurrent VTE, but the mechanisms are elusive. Procoagulant phospholipids ...

    • Scale-space methodology applied to spectral feature detection, multinormality testing and the k-sample problem, and wavelet variance analysis 

      Hindberg, Kristian (Doctoral thesis; Doktorgradsavhandling, 2012-03-23)
      The number of scale-space statistical algorithms has been greatly increased over the last 15 years. The concept originated from computer vision, introduced in Lindeberg (1994). The seminal paper by Chaudhuri and Marron (1999) brought the scale-space concept into smoothing of curves and kernel density estimation through the SiZer tool. By using all relevant smoothing bandwidths, i.e., the scale part, ...

    • Using anchors from free text in electronic health records to diagnose postoperative delirium 

      Mikalsen, Karl Øyvind; Soguero-Ruiz, Cristina; Jensen, Kasper; Hindberg, Kristian; Gran, Mads; Revhaug, Arthur; Lindsetmo, Rolv-Ole; Skrøvseth, Stein Olav; Godtliebsen, Fred; Jenssen, Robert (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-19)
      Objectives:<br> Postoperative delirium is a common complication after major surgery among the elderly. Despite its potentially serious consequences, the complication often goes undetected and undiagnosed. In order to provide diagnosis support one could potentially exploit the information hidden in free text documents from electronic health records usin ...