• Structure-function relationships in the nasal cavity of Arctic and subtropical seals 

      Cheon, Hyejeong; Kjelstrup, Signe; Kizilova, Nataliya; Flekkøy, Eirik Grude; Mason, Matthew J.; Folkow, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-14)
      The heating and moistening of inhaled air, and the cooling and moisture removal from exhaled air, are crucial for the survival of animals under severe environmental conditions. Arctic mammals have evolved specific adaptive mechanisms to retain warmth and water and restrict heat loss during breathing. Here, the role of the porous turbinates of the nasal cavities of Arctic and subtropical seals is ...
    • Terrestrial locomotion of the Svalbard rock ptarmigan: comparing field and laboratory treadmill studies 

      Marmol-Guijarro, Andres C; Nudds, Robert L.; Marrin, John C; Folkow, Lars; Codd, Jonathan R (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-07)
      Research into the terrestrial locomotion of birds is often based upon laboratory treadmill experiments. However, it is unclear how transposable these results are for birds moving in the wild. Here, using video recordings, we compared the kinematics of locomotion (stride frequency, stride length, stance phase, swing phase, duty factor) and speed range of Svalbard rock ptarmigan (<i>Lagopus muta ...
    • Thermal modeling of the respiratory turbinates in arctic and subtropical seals 

      Flekkøy, Eirik Grude; Folkow, Lars; Kjelstrup, Signe; Mason, Matthew J.; Wilhelmsen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-06)
      Mammals possess complex structures in their nasal cavities known as respiratory turbinate bones, which help the animal to conserve body heat and water during respiratory gas exchange. We considered the function of the maxilloturbinates of two species of seals, one arctic (<i>Erignathus barbatus</i>), one subtropical (<i>Monachus monachus</i>). By means of a thermo-hydrodynamic model that describes ...
    • Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids 

      Lean, Fabian Z.X.; Cox, Ruth; Madslien, Knut; Spiro, Simon; Nymo, Ingebjørg Helena; Bröjer, Caroline; Neimanis, Aleksija; Lawson, Becki; Holmes, Paul; Man, Catherine; Folkow, Lars; Gough, Julie; Ackroyd, Stuart; Evans, Liam; Wrigglesworth, Ethan; Grimholt, Unni; McElhinney, Lorraine; Brookes, Sharon M.; Delahay, Richard J.; Núñez, Alejandro (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-25)
      Natural cases of zooanthroponotic transmission of SARS-CoV-2 to animals have been reported during the COVID-19 pandemic, including to free-ranging white-tailed deer (<i>Odocoileus virginianus</i>) in North America and farmed American mink (<i>Neovison vison</i>) on multiple continents. To understand the potential for angiotensin-converting enzyme 2 (ACE2)-mediated viral tropism we characterised the ...
    • Transcriptome analysis identifies key metabolic changes in the hooded seal (Cystophora cristata) brain in response to hypoxia and reoxygenation 

      Hoff, Mariana Leivas Müller; Fabrizius, Andrej; Czech-Damal, Nicole U.; Folkow, Lars; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-03)
      The brain of diving mammals tolerates low oxygen conditions better than the brain of most terrestrial mammals. Previously, it has been demonstrated that the neurons in brain slices of the hooded seal (Cystophora cristata) withstand hypoxia longer than those of mouse, and also tolerate reduced glucose supply and high lactate concentrations. This tolerance appears to be accompanied by a shift in the ...
    • Transcriptome analysis reveals a high aerobic capacity in the whale brain 

      Kruger, Alena; Fabrizius, Andrej; Mikkelsen, Bjarni; Siebert, Ursula; Folkow, Lars; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-30)
      The brain of diving mammals is repeatedly exposed to low oxygen conditions (hypoxia) that would have caused severe damage to most terrestrial mammals. Some whales may dive for > 2 h with their brain remaining active. Many of the physiological adaptations of whales to diving have been investigated, but little is known about the molecular mechanisms that enable their brain to survive sometimes ...
    • Transcriptomes Suggest That Pinniped and Cetacean Brains Have a High Capacity for Aerobic Metabolism While Reducing Energy-Intensive Processes Such as Synaptic Transmission 

      Geßner, Cornelia; Krüger, Alena; Folkow, Lars; Fehrle, Wilfrid; Mikkelsen, Bjarni; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-09)
      The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of most terrestrial mammals suffer from irreversible damage after only short periods of hypoxia, neurons of the deep-diving hooded seal (Cystophora cristata) show ...
    • When the brain goes diving: transcriptome analysis reveals a reduced aerobic energy metabolism and increased stress proteins in the seal brain 

      Fabrizius, Andrej; Hoff, Mariana Leivas Müller; Engler, Gerhard; Folkow, Lars; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-09)
      <b>Background: </b>During long dives, the brain of whales and seals experiences a reduced supply of oxygen (hypoxia). The brain neurons of the hooded seal (Cystophora cristata) are more tolerant towards low-oxygen conditions than those of mice, and also better survive other hypoxia-related stress conditions like a reduction in glucose supply and high concentrations of lactate. Little is known ...
    • Why Rudolph's nose is red: observational study 

      Ince, Can; van Kuijen, Anne-Marie; Milstein, Dan M J; Yürük, Koray; Folkow, Lars; Fokkens, Wytske J; Blix, Arnoldus S (Journal article; Tidsskriftartikkel, 2012-12-17)
      Objective To characterise the functional morphology of the nasal microcirculation in humans in comparison with reindeer as a means of testing the hypothesis that the luminous red nose of Rudolph, one of the most well known reindeer pulling Santa Claus’s sleigh, is due to the presence of a highly dense and rich nasal microcirculation.<p> <p>Design Observational study.<p> <p>Setting Tromsø, ...